Biography

Hiromi Yanagisawa, M.D., Ph.D. graduated from the School of Medicine, University of Tsukuba, Japan with MD in 1986 and Ph.D. in 1993. After completing residency in Internal Medicine, she moved to the University of Texas Southwestern Medical Center and worked in the laboratories of Dr. Robert Hammer and Dr. Eric Olson. In 2003, she was appointed as Assistant Professor in Molecular Biology and promoted to Associate Professor with tenure in 2011. Her laboratory works to define pathophysiological roles of extracellular matrix proteins in cardiovascular, renal, urogenital systems and how they modulate intercellular signaling, cellular functions and cell fate. She is also interested in molecular mechanism of neural crest development, focusing on craniofacial and cardiovascular development. 

Education

Medical School University of Tsukuba - ? (1986), Medicine
Graduate School University of Tsukuba - ? (1993), Medicine

Research Interest

  • Developmental program of neural crest-derived tissues
  • ECM and tumor angiogenesis
  • Elastic fiber formation in vivo
  • Molecular mechanism of vascular development
  • Regulation and signaling during cardiovascular remodeling

Publications

Featured Publications LegendFeatured Publications

Tbx1 regulates oral epithelial adhesion and palatal development.

Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H Hum. Mol. Genet. 2012 Jun 21 11 2524-37

Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.

Schluterman MK, Chapman SL, Korpanty G, Ozumi K, Fukai T, Yanagisawa H, Brekken RA Dis Model Mech 2010 May-Jun 3 5-6 333-42

Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury.

Chapman SL, Sicot FX, Davis EC, Huang J, Sasaki T, Chu ML, Yanagisawa H Arterioscler. Thromb. Vasc. Biol. 2010 Jan 30 1 68-74

Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2.

Funato N, Chapman SL, McKee MD, Funato H, Morris JA, Shelton JM, Richardson JA, Yanagisawa H Development 2009 Feb 136 4 615-25

Honors & Awards

  • Established Investigator Award
    American Heart Association (2012)
  • Junior Investigator Award
    American Society for Matrix Biology (2008)

Professional Associations/Affiliations

  • North American Vascular Biology Organization (2004)
  • Society for Developmental Biology (2003)
  • American Heart Association (2001)
  • American Society for Matrix Biology (2001)