Hiromi Yanagisawa, M.D., Ph.D. graduated from the School of Medicine, University of Tsukuba, Japan with MD in 1986 and Ph.D. in 1993. After completing residency in Internal Medicine, she moved to the University of Texas Southwestern Medical Center and worked in the laboratories of Dr. Robert Hammer and Dr. Eric Olson. In 2003, she was appointed as Assistant Professor in Molecular Biology and promoted to Associate Professor with tenure in 2011. Her laboratory works to define pathophysiological roles of extracellular matrix proteins in cardiovascular, renal, urogenital systems and how they modulate intercellular signaling, cellular functions and cell fate. She is also interested in molecular mechanism of neural crest development, focusing on craniofacial and cardiovascular development.
|Medical School||University of Tsukuba - ? (1986), Medicine|
|Graduate School||University of Tsukuba - ? (1993), Medicine|
- Developmental program of neural crest-derived tissues
- ECM and tumor angiogenesis
- Elastic fiber formation in vivo
- Molecular mechanism of vascular development
- Regulation and signaling during cardiovascular remodeling
- Angiotensin-converting enzyme-induced activation of local Angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.
- Huang J, Yamashiro Y, Papke CL, Ikeda Y, Lin Y, Patel M, Inagami T, Le VP, Wagenseil JE, Yanagisawa H Sci Transl Med 2013 May 5 183 183ra58
- Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans.
- Budatha M, Roshanravan S, Zheng Q, Weislander C, Chapman SL, Davis EC, Starcher B, Word RA, Yanagisawa H J. Clin. Invest. 2011 May 121 5 2048-59
- Unraveling the mechanism of elastic fiber assembly: The roles of short fibulins.
- Yanagisawa H, Davis EC Int. J. Biochem. Cell Biol. 2010 Jul 42 7 1084-93
- Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression.
- Huang J, Davis EC, Chapman SL, Budatha M, Marmorstein LY, Word RA, Yanagisawa H Circ. Res. 2010 Feb 106 3 583-92
- Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration.
- Spencer JA, Hacker SL, Davis EC, Mecham RP, Knutsen RH, Li DY, Gerard RD, Richardson JA, Olson EN, Yanagisawa H Proc. Natl. Acad. Sci. U.S.A. 2005 Feb 102 8 2946-51
- Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo.
- Yanagisawa H, Davis EC, Starcher BC, Ouchi T, Yanagisawa M, Richardson JA, Olson EN Nature 2002 Jan 415 6868 168-71
- Tbx1 regulates oral epithelial adhesion and palatal development.
- Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H Hum. Mol. Genet. 2012 Jun 21 11 2524-37
- Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.
- Schluterman MK, Chapman SL, Korpanty G, Ozumi K, Fukai T, Yanagisawa H, Brekken RA Dis Model Mech 2010 May-Jun 3 5-6 333-42
- Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury.
- Chapman SL, Sicot FX, Davis EC, Huang J, Sasaki T, Chu ML, Yanagisawa H Arterioscler. Thromb. Vasc. Biol. 2010 Jan 30 1 68-74
- Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2.
- Funato N, Chapman SL, McKee MD, Funato H, Morris JA, Shelton JM, Richardson JA, Yanagisawa H Development 2009 Feb 136 4 615-25
Honors & Awards
- Established Investigator Award
American Heart Association (2012)
- Junior Investigator Award
American Society for Matrix Biology (2008)
- North American Vascular Biology Organization (2004)
- Society for Developmental Biology (2003)
- American Heart Association (2001)
- American Society for Matrix Biology (2001)