Biography

Research and Professional Experience

1980-1985 Graduate Research Assistant, Department of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY  PhD Thesis Advisor: Efraim Racker, MD

1985-1987 Research Assistant Professor Dept. Internal Medicine, UT Southwestern Medical Center

1987-1990 Assistant Professor, Department of Physiology, UT Southwestern Medical Center

1987-present Member of Graduate Faculty, Graduate Program of Biological Chemistry, UT Southwestern Graduate school of Biomedical Sciences

1990-1998 Associate Professor of Internal Medicine and Physiology, Department of Internal Medicine, UT Southwestern

1998-present Professor of Internal Medicine, Department of Internal Medicine, UT Southwestern

2001-present Professor of Internal Medicine, McDermott Center for Human Growth and Development, UT Southwestern

Research Projects Ongoing or Completed During the last Three years:

  1. Structure and Function of ABCG5 and ABCG8.

 The long-term goal of this project is to determine the structure and function of this important ABC transport system and to understand the mechanism by which this ABC transporter translocates sterols across membranes.  The project in the current phase is focusing on the role of intestinal expressed ABCG5/ABCG8 and the high-resolution structure of it.

  1. The Structure and Function of Mammalian V-type proton Translocation ATPases.

The long-term goal of this project is to determine the structural basis of the function and regulation of V-type proton pumps. The project characterizes the catalytic center and a regulatory component of the V-type proton pump of clathrin-coated vesicles and studies the isoform structure of the major subunits in its membrane domain to determine the structural basis for the regulation of this pump

  1. Lipid asymmetry in plasma membrane and Apoptosis-induced PS exposure

The long-term goal of this project is to elucidate the mechanism by which the maintenance of lipid asymmetry in plasma membrane and PS exposure during apoptosis are regulated.

Education

Undergraduate Beijing University - China (1975)
Graduate School Cornell University (1985)

Research Interest

  • Biochemistry of ABC transporters-ABCG5 and ABCG8.
  • Structure and function of V-type Proton translocating ATPase.

Publications

Featured Publications LegendFeatured Publications

Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8.
Wang J, Zhang DW, Lei Y, Xu F, Cohen JC, Hobbs HH, Xie XS Biochemistry 2008 May 47 18 5194-204
Three-dimensional reconstruction of bovine brain V-ATPase by cryo-electron microscopy and single particle analysis
Marco Gregorini, Jin Wang, Xiao-Song Xie, Ronald, Milligan, Andreas, Engel Journal of Structural Biology June 2007 Vol. 158 pp.445-454
C. elegans mitochondrial factor WAH-1 promotes PS externalization in apoptotic cells through phospholipid scramblase SCRM-1
Xiaochen Wang, Jin Wang, Keiko Gengyo-Ando, Lichan Gu, Chen-Ling sun, Chonglin Yang, Yong Shi, TetsuoKobayashi, Yigong Shi, Shohei Mitani, Xiao-Song Xie, and Ding Xue Nature Cell Biology May 2007 Vol. 9 pp.541-549
Sterol Transfer by ABCG5 and ABCG8
Jin Wang, Fang Sun, Da-wei Zhang, Yongming Ma, Fang Xu, Jitendra belani, Jonathan Cohen, Helen, Hobbs, and Xiao-Song Xie Journal of Biologicla Chemistry September 2006 Vol. 281 pp.27894-27904
Salicylihalamide A inhibits the Vo sector of the V-ATPase through a mechanism distinct from Bafilomycin A1
Xie, X.-S., Padron, D., Liao, X., Wang, J., Roth, M.G., De Brabander, J.K. Journal of Biological Chemistry May 2004 279 19755-19763
Characterization of the functional coupling of bovine brain V-ATPase: Effect of divalent cations, phospholipids, and subunit H(SFD)
Crider, B. and Xie, X.-S. Journal of Biological Chemistry November 2003 278 44281-44288

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology