Richard Wynn, Ph.D.

Richard Wynn, Ph.D., is an Associate Professor in the Departments of Internal Medicine and Biochemistry at UT Southwestern Medical Center and a member of the Division of General Internal Medicine.

Originally from Levelland, Texas, Dr. Wynn holds a bachelor's degree in chemistry and biology from McMurry University in Abilene, Texas. He also holds a master's degree in chemistry and biochemistry as well as his medical degree from Texas Tech University in Lubbock. He completed postdoctoral work at the University of California-Berkeley.

Dr. Wynn joined the UT Southwestern faculty in 1994 as an Assistant Professor. He was promoted to Associate Professor in 2006.

At UT Southwestern, Dr. Wynn is a medical school interviewer and a member of the Medical School Admissions Committee.

Graduate School

Texas Tech University (1983), Chemistry

Graduate School

Texas Tech University (1986), Chemistry

• Cancer
• Diabetes and Glucose metabolism
• Heat shock and chaperone proteins
• Inborn errors of metabolism
• Structure and function of mitochondrial multienzyme complexes

Featured Publications

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.

Zhou M, Jing S, Wu CY, Shu L, Dong W, Liu Y, Chen M, Wynn RM, Wang J, Wang J, Gui WJ, Qi X, Lusis AJ, Li Z, Wang W, Ning G, Yang X, Chuang DT, Wang Y, Sun H, Diabetes 2019 Jun

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, Zhang GF, Ilkayeva O, Herman MA, Wynn RM, Chuang DT, Newgard CB Cell Metab. 2018 May

A Novel Inhibitor of Pyruvate Dehydrogenase Kinase Stimulates Myocardial Carbohydrate Oxidation in Diet-Induced Obesity.

Wu CY, Satapati S, Gui W, Wynn RM, Sharma G, Lou M, Qi X, Burgess SC, Malloy C, Khemtong C, Sherry AD, Chuang D, Merritt ME J. Biol. Chem. 2018 May

Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.

Wu CY, Tso SC, Chuang JL, Gui WJ, Lou M, Sharma G, Khemtong C, Qi X, Wynn RM, Chuang DT Mol Metab 2018 Mar

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

Tso SC, Lou M, Wu CY, Gui WJ, Chuang JL, Morlock LK, Williams NS, Wynn RM, Qi X, Chuang DT J. Med. Chem. 2017 Jan

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain a-Ketoacid Dehydrogenase Kinase.

Tso SC, Gui WJ, Wu CY, Chuang JL, Qi X, Skvorak KJ, Dorko K, Wallace AL, Morlock LK, Lee BH, Hutson SM, Strom SC, Williams NS, Tambar UK, Wynn RM, Chuang DT J. Biol. Chem. 2014 Jun

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket.

Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, Scherer PE, Williams NS, Tambar UK, Wynn RM, Chuang DT J. Biol. Chem. 2014 Feb 289 7 4432-43

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain a-ketoacid dehydrogenase kinase.

Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT Proc. Natl. Acad. Sci. U.S.A. 2013 May

Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain {alpha}-Ketoacid Dehydrogenase Complex.

Brautigam CA, Wynn RM, Chuang JL, Naik MT, Young BB, Huang TH, Chuang DT J. Biol. Chem. 2011 Jul 286 26 23476-88

Phenylbutyrate therapy for maple syrup urine disease.

Brunetti-Pierri N, Lanpher B, Erez A, Ananieva EA, Islam M, Marini JC, Sun Q, Yu C, Hegde M, Li J, Wynn RM, Chuang DT, Hutson S, Lee B Hum. Mol. Genet. 2011 Feb 20 4 631-40

 Featured Books

Maple Syrup Urine Disease: Clinical and Therapeutic Considerations. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

David T. Chuang, R. Max Wynn, Rody P. Cox and Jacinta L. Chuang (2014). San Diego, CA, Elsevier

• Distinguished Alumni
  Distinguished Alumni at McMurry University, Abilene, Texas (2014-2015)

• Metabolic Phenotyping Core (2020)