Education

Graduate School Texas Tech University (1983)
Graduate School Texas Tech University (1986)

Research Interest

  • Cancer
  • Diabetes and Glucose metabolism
  • Heat shock and chaperone proteins
  • Inborn errors of metabolism
  • Structure and function of mitochondrial multienzyme complexes

Publications

Featured Publications LegendFeatured Publications

Determination of Protein Complex Stoichiometry Though Multisignal Sedimentation Velocity Experiments. Anal Biochem. Jul 24. [Epub ahead of print] PMID: 20667444.
Padrick, S.B., Deka, R.K., Chuang, J.L., Wynn, R.M., Chuang, D.T., Norgard, M.V., Rosen, M.K. and Brautigam, C.A.
Structure-based Development of a Robust Novel Inhibitor for Mitochondrial Branched-chain α-Ketoacid Dehydrogenase Kinase.
Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Jacinta L. Chuang, Lorraine K. Morlock, Amy L. Wallace, Kamran Ahmed, Sunil Laxman, Philippe M. Campeau, Brendan H. Lee, Susan M. Hutson, Benjamin P. Tu, Noelle S. Williams, Uttam K.Tambar, R. Max Wynn, and David T. Chuang. PNAS 2013
Structural and Biochemical Characterization of Human Mitochondrial Branched-chain a-Ketoacid Dehydrogenase Phosphatase.
Wynn, R.M., Jun Li, Chad A. Brautigam, Jacinta L. Chuang, and David T. Chuang JBC 2012 287 9178-92
Structural characterization of a unique interface between Carbohydrate Response Element Binding Protein (ChREBP) and 14-3-3ß
Qiang Ge, Niang Huang, R. Max Wynn, Yang Li, Xinlin Du, Bonnie Miller, Hong Zhang and Kosaku Uyeda JBC 2012 287 41914-21
Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm).
Islam MM, Nautiyal M, Wynn RM, Mobley JA, Chuang DT, Hutson SM J. Biol. Chem. 2010 Jan 285 1 265-76