Biography

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Dr. Carol Wise is Director of Basic Research at Texas Scottish Rite Hospital for Children and Professor in the McDermott Center for Human Growth and Development? and departments of Orthopaedic Surgery and Pediatrics at UTSW. Originally from Texas, she received her undergraduate degree in chemistry from Texas A&M University and her doctorate degree in biochemistry from The University of Texas Southwestern Medical Center at Dallas. She completed postdoctoral fellowships in human molecular genetics with James Lupski at Baylor College of Medicine in Houston and with Michael Lovett at The University of Texas Southwestern Medical Center at Dallas. Dr. Wise is a founding member and chair of the International Consortium for Spinal Genetics, Development, and Disease. She also co-directs the TSRHC GOOD for KIDs program aimed at solving rare debilitating musculoskeletal diseases in children using next-generation genomic methods. Dr. Wise’s laboratory hosts the TSRHC Scoliosis Biobank and the U.S. DNA and Cell repository for the Primordial Registry, a joint effort with Dr. Michael Bober at A. I. duPont Hospital for Children. Dr. Wise leads NIH-funded projects focused on mechanistic understanding of adolescent idiopathic scoliosis, the most common musculoskeletal disorder in children, and on earlier onset forms. 

Education

Undergraduate
Texas A & M University (1985), Chemistry
Graduate School
UT Southwestern Medical Center (1991), Biochemistry

Research Interest

  • Genetic and Biochemical Causes of Pediatric Musculoskeletal Disorders
  • Genetics Risk Factors for Idiopathic Scoliosis

Publications

Featured Publications LegendFeatured Publications

Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia.
Gray MJ, Kannu P, Sharma S, Neyt C, Zhang D, Paria N, Daniel PB, Whetstone H, Sprenger HG, Hammerschmidt P, Weng A, Dupuis L, Jobling R, Mendoza-Londono R, Dray M, Su P, Wilson MJ, Kapur RP, McCarthy EF, Alman BA, Howard A, Somers GR, Marshall CR, Manners S, Flanagan AM, Rathjen KE, Karol LA, Crawford H, Markie DM, Rios JJ, Wise CA, Robertson SP Am. J. Hum. Genet. 2015 Dec 97 6 837-47
A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females.
Sharma S, Londono D, Eckalbar WL, Gao X, Zhang D, Mauldin K, Kou I, Takahashi A, Matsumoto M, Kamiya N, Murphy KK, Cornelia R, Herring JA, Burns D, Ahituv N, Ikegawa S, Gordon D, Wise CA Nat Commun 2015 6 6452
Neurofibromin Deficiency-Associated Transcriptional Dysregulation Suggests a Novel Therapy for Tibial Pseudoarthrosis in NF1.
Paria N, Cho TJ, Choi IH, Kamiya N, Kayembe K, Mao R, Margraf RL, Obermosser G, Oxendine I, Sant DW, Song MH, Stevenson DA, Viskochil DH, Wise CA, Kim HK, Rios JJ J. Bone Miner. Res. 2014 Jun
ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease.
Hayes M, Gao X, Yu LX, Paria N, Henkelman RM, Wise CA, Ciruna B Nat Commun 2014 5 4777
Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly.
Rios JJ, Paria N, Burns DK, Israel BA, Cornelia R, Wise CA, Ezaki M Hum. Mol. Genet. 2013 Feb 22 3 444-51
Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.
Bicknell LS, Walker S, Klingseisen A, Stiff T, Leitch A, Kerzendorfer C, Martin CA, Yeyati P, Al Sanna N, Bober M, Johnson D, Wise C, Jackson AP, O'Driscoll M, Jeggo PA Nat. Genet. 2011 Apr 43 4 350-5
Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.
Sharma S, Gao X, Londono D, Devroy SE, Mauldin KN, Frankel JT, Brandon JM, Zhang D, Li QZ, Dobbs MB, Gurnett CA, Grant SF, Hakonarson H, Dormans JP, Herring JA, Gordon D, Wise CA Hum. Mol. Genet. 2011 Apr 20 7 1456-66

Books

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Honors & Awards

  • Russell A. Hibbs Basic Science Award, Scoliosis Research Society
    (2014)
  • Russell A. Hibbs Basic Science Award, Scoliosis Research Society
    (2012)
  • Distinguished Service Award, Texas Genetics Society
    (2011)
  • Community Builder Award, Brooklyn Lodge
    (2010)
  • Anson Jones Award, Ft. Worth Scottish Rite Foundation
    (2009)
  • Community Builder Award, John L. DeGrozier Lodge
    (2009)
  • Forney High School Hall of Honor
    (2009)
  • Texas Trailblazer, The Family Place
    (2008)
  • YWCA Centennial Award
    (2007)

Professional Associations/Affiliations

  • University of Texas Southwestern Medical Center (1997)
  • Texas Scottish Rite Hospital for Children (1996)