Dr. Carol Wise is director of Molecular Genetics at Texas Scottish Rite Hospital for Children and Associate Professor of Orthopaedic Surgery, Pediatrics, and McDermott Center for Human Growth and Development at University of Texas Southwestern Medical Center. Originally from Texas, she received her undergraduate degree in chemistry from Texas A&M University and her doctorate degree in biochemistry from The University of Texas Southwestern Medical Center at Dallas. She completed postdoctoral fellowships in human molecular genetics with Dr. James Lupski at Baylor College of Medicine in Houston and with Dr. Michael Lovett at The University of Texas Southwestern Medical Center at Dallas. Dr. Wise’s research focuses on understanding the genetic causes of inherited pediatric musculoskeletal conditions. She applies both family- and population-based methods to identify the genetic risk factors for idiopathic scoliosis, and she is founding member and chair of the International Consortium for Scoliosis Genetics. Dr. Wise also co-directs the TSRHC GOOD for KIDs program, a study that applies next-generation genomic methods to gene discovery for rare, debilitating musculoskeletal diseases in children. Dr. Wise’s laboratory hosts the U.S. DNA and cell repository for the Primordial Registry, a joint effort with Dr. Michael Bober at A. I. duPont Hospital for Children. She is also a member of various professional societies, including the Scoliosis Research Society, the Pediatric Orthopaedic Society of North America, and the American Society of Human Genetics. She is a member and past president of the Texas Genetics Society. 


Office: (214) 559-7877 or (800) 421-1121, ext. 7877


Texas A & M University (1985), Chemistry
Graduate School
UT Southwestern Medical Center (1991), Biochemistry

Research Interest

  • Genetic and Biochemical Causes of Pediatric Musculoskeletal Disorders
  • Genetics Risk Factors for Idiopathic Scoliosis


Featured Publications LegendFeatured Publications

Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly.
Rios JJ, Paria N, Burns DK, Israel BA, Cornelia R, Wise CA, Ezaki M Hum. Mol. Genet. 2013 Feb 22 3 444-51
The impact of large-scale genomic methods in orthopaedic disorders: insights from genome-wide association studies.
Nandina Paria, Lawson A. Copley, John A. Herring, Harry K. W. Kim, B. Stephens Richards, Daniel J. Sucato, Jonathan J. Rios, Carol A. Wise J Bone Joint Surgery 2013
Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.
Bicknell LS, Walker S, Klingseisen A, Stiff T, Leitch A, Kerzendorfer C, Martin CA, Yeyati P, Al Sanna N, Bober M, Johnson D, Wise C, Jackson AP, O'Driscoll M, Jeggo PA Nat. Genet. 2011 Apr 43 4 350-5
Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.
Sharma S, Gao X, Londono D, Devroy SE, Mauldin KN, Frankel JT, Brandon JM, Zhang D, Li QZ, Dobbs MB, Gurnett CA, Grant SF, Hakonarson H, Dormans JP, Herring JA, Gordon D, Wise CA Hum. Mol. Genet. 2011 Apr 20 7 1456-66
Mutations in the pre-replication complex cause Meier-Gorlin syndrome.
Bicknell LS, Bongers EM, Leitch A, Brown S, Schoots J, Harley ME, Aftimos S, Al-Aama JY, Bober M, Brown PA, van Bokhoven H, Dean J, Edrees AY, Feingold M, Fryer A, Hoefsloot LH, Kau N, Knoers NV, Mackenzie J, Opitz JM, Sarda P, Ross A, Temple IK, Toutain A, Wise CA, Wright M, Jackson AP Nat. Genet. 2011 43 4 356-9
CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis.
Gao X, Gordon D, Zhang D, Browne R, Helms C, Gillum J, Weber S, Devroy S, Swaney S, Dobbs M, Morcuende J, Sheffield V, Lovett M, Bowcock A, Herring J, Wise C Am. J. Hum. Genet. 2007 May 80 5 957-65

Honors & Awards

  • Russell A. Hibbs Basic Science Award, Scoliosis Research Society
  • Distinguished Service Award, Texas Genetics Society
  • Community Builder Award, Brooklyn Lodge
  • Anson Jones Award, Ft. Worth Scottish Rite Foundation
  • Community Builder Award, John L. DeGrozier Lodge
  • Forney High School Hall of Honor
  • Texas Trailblazer, The Family Place
  • YWCA Centennial Award