Thomas Wilkie, Ph.D.

Associate Professor

Department: Pharmacology

Graduate Programs: Genetics and Development, Integrative Biology

Biography

Education

1980 BA, Biochemistry Department, University of California, Berkeley

1987 PhD, Biochemistry Department, University of Washington, with Dr. Richard D. Palmiter Thesis: Transmission Ratio Distortion and Mosaicism in Transgenic Mice Postdoctoral Training 1986-1992 NIH Postdoctoral Fellow with Dr. Melvin I. Simon California Institute of Technology, Pasadena CA

Academic Appointments

1993 Assistant Professor, Department of Pharmacology

2000 Associate Professor, Department of Pharmacology

Education

Undergraduate University of California-Berkeley (), Biochemistry
Undergraduate University of California-Berkeley (1980), Biochemistry
Graduate School University of Washington (1986), Biochemistry

Research Interests

  • G Protein Signaling in Pancreas Development, Adult Physiology and Behavior
  • Pancreatic cancer
  • Pancreatic islet and beta cell expansion in diabetes

Publications

Featured Publications Legend

Featured Publications

New roles for G alpha and RGS proteins: Communication continues despite driving sisters apart.

Wilkie TM & Kinch L. Current Biology November 2005 15 R843-R854

G alpha-q and G alpha-11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.

Ivey K, Tyson B, Ukidwe P, McFadden D, Levi G, Olson E, Srivastava D & Wilkie TM Developmental Biology 2003 255 230-237

Regulators of G protein signaling provide biochemical control of agonist-evoked [Ca2+]i oscillations.

Luo X, Popov S, Bera AK, Wilkie TM & Muallem S Molecular Cell 2001 7 651-660

The N-terminal domain of RGS4 confers receptor selective inhibition of G protein signaling

Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff K, Fisher S, Ross EM, Muallem S & Wilkie TM J. Biol. Chem. 1998 273 34687-34690

The RGS domains of RGS4, RGS10 and GAIP retain GAP activity in vitro.

Popov S, Yu K, Kozasa T & Wilkie TM Proc. Natl. Acad Sci. USA 1997 94 7216-7220

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Books

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Featured Books

Honors/Awards

  • Editorial Board
    Journal of Biological Chemistry (2007)
  • Editorial Board
    Nature Molecule Pages (2002)
  • Established Investigator Award
    American Heart Association (1996)
  • Basil OConner MOD
    Starter Scholar Research Award (1995)

Professional Associations/Affiliations

  • AACR (2010)
  • ASPET (1996)
  • ASBMB (1988)