Featured Publications
Regulator of G protein Signaling (Rgs16) inhibits hepatic fatty acid oxidation in a ChREBP-dependent manner
Pashkov V*, Huang J*, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Gerard RD, Esser V, Uyeda K, Towle H & Wilkie TM J Biol Chem April 2011 286 [Cover] 15116-15127
Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes
Villasenor A, Wang ZV, Rivera LB, Ocal O, Wernstedt Asterholm I, Scherer PE, Brekken RA, Cleaver O*, & Wilkie TM* Disease Models & Mechanisms September 2010 3 567-580
GTPase-activating proteins (GAPs) for heterotrimeric G proteins: Regulators of G protein signaling (RGS proteins) and their relatives.
Ross EM & Wilkie TM Annual Review of Biochemistry 2000 69 795-827
Ca2+/calmodulin reverses 3,4,5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.
Popov S, Krishna UM, Falck JR & Wilkie TM J. Biol. Chem. 2000 275 18962-18968
GAIP and RGS4 are GTPase accelerating proteins (GAPs) for the Gi family of heterotrimeric guanine nucleotide binding proteins.
Berman DM, Wilkie TM & Gilman AG Cell 1996 86 445-452
New roles for G alpha and RGS proteins: Communication continues despite driving sisters apart.
Wilkie TM & Kinch L. Current Biology November 2005 15 R843-R854
G alpha-q and G alpha-11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.
Ivey K, Tyson B, Ukidwe P, McFadden D, Levi G, Olson E, Srivastava D & Wilkie TM Developmental Biology 2003 255 230-237
Regulators of G protein signaling provide biochemical control of agonist-evoked [Ca2+]i oscillations.
Luo X, Popov S, Bera AK, Wilkie TM & Muallem S Molecular Cell 2001 7 651-660
The N-terminal domain of RGS4 confers receptor selective inhibition of G protein signaling
Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff K, Fisher S, Ross EM, Muallem S & Wilkie TM J. Biol. Chem. 1998 273 34687-34690
The RGS domains of RGS4, RGS10 and GAIP retain GAP activity in vitro.
Popov S, Yu K, Kozasa T & Wilkie TM Proc. Natl. Acad Sci. USA 1997 94 7216-7220
