Education

Undergraduate University of Iowa (1986)
Graduate School University of North Carolina at Chapel Hill (1992)

Research Interest

  • Cancer
  • Molecular architecture of growth regulatory signal transduction cascades
  • Oncogenes
  • Signal transduction
  • Tumor Suppressors

Publications

Featured Publications LegendFeatured Publications

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation.
OU YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T, Tan SL, White MA. Molecular Cell February 2011 41/4 458-470
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.
Bodemann BO, Orvedahl A, Cheng T, Ram RR, Ou YH, Formstecher E, Maiti M, Hazelett CC, Wauson EM, Balakireva M, Camonis JH, Yeaman C, Levine B, White MA. Cell January 2011 144 253-267
Functional genomics of chemosensitivity exposes deviant cancer cell regulatory systems.
Whitehurst, A. W., Bodemann, B. O., Cardenas, J., Ferguson, D., Girard, L., Payton, M., Minna, J. D., Michnoff, C., Hao, W., Roth, M. G., Xie X.-J., and White, M. A. Nature 2007 446 815-820
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival
Chien Y, Kim S, Bumeister R, Loo YM, Kwon SW, Johnson CL, Balakireva MG, Romeo Y, Kopelovich L, Gale M Jr, Yeaman C, Camonis JH, Zhao Y, White MA Cell October 2006 6 157-170
Ras regulates assembly of mitogenic signaling complexes through the novel effector protein IMP.
Matheny, S., Chen, C., Kortum, R., Razidlo, G., Lewis, R., and White, M. A. Nature 2004 427 256-260

Honors & Awards

  • Grant A. Dove Distinguished Chair for Research in Oncology
    (2011)
  • The Sherry Wigley Crow Cancer Research Endowed Chair in Honor of Robert Lewis Kirby, M.D.
    (2009)
  • Hortense and Morton Sanger Professorship in Oncology
    (2008)