Charles L. White, III, M.D., is Professor of Pathology and holds the Nancy R. McCune Distinguished Chair in Alzheimer Disease Research. He has been the Director of Neuropathology at UT Southwestern since completing his residency and fellowship training in anatomic pathology and neuropathology at Johns Hopkins in 1983.

Dr. White’s clinical and research interests focus on neurodegenerative brain disorders. He has been the director of the Neuropathology Core of the UT Southwestern Alzheimer Disease Center, funded by the National Institute on Aging, since its inception in 1988. He also directs the Winspear Family Special Center for Research on the Neuropathology of Alzheimer's Disease, established at UT Southwestern in 2002 by a generous gift from the Bill and Margot Winspear Family.

Dr. White is the Training Director for the Neuropathology Fellowship program at UT Southwestern, an ACGME-accredited, 2-year training program. Fourteen trainees have completed the program and become board certified by the American Board of Pathology in the subspecialty of Neuropathology.

Dr. White is past president of the American Association of Neuropathologists, the national professional organization for neuropathologists in the US.


Medical School University of Arizona College of Med. (1978)
Internship Johns Hopkins Hospital (1979), Pathology
Residency Johns Hopkins Hospital (1981), Pathology
Fellowship Johns Hopkins University School of Medicine (1983), Neuropathology

Specialty Areas

Clinical Interest

  • Forensic Neuropathology
  • Neurodegenerative Disorders
  • Neuropathology

Research Interest

  • Alzheimer disease
  • Forensic neuropathology
  • Immunohistochemistry
  • Neurodegenerative disorders
  • Tissue microarray technology


Featured Publications LegendFeatured Publications

TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a Midwest-Southwest Consortium for FTLD study
Hatanpaa KJ, Bigio EH, Cairns NJ, Womack KB, Weintraub S, Morris JC, Foong C, Xiao G, Hladik C, Mantanona TY, White CL III J Neuropathol Exp Neurol 2008 67 271-279
Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia
Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, Goate A Hum Mutat 2008 29 512-521
Mutations in progranulin are a major cause of ubiqutin-positive frontotemporal lobar degeneration
Gass J, Cannon A, Mackenzie IR, et al. Hum Mol Genet 2006 15 2988-3001
Frontotemporal lobar degeneration with motor neuron disease-type inclusions predominates in 76 cases of frontotemporal degeneration.
Lipton AM, White CL III, Bigio EH Acta Neuropathol 2004 108 379-385
Alpha-synuclein expression in the developing human brain
Raghavan R, de Kruijff L, Sterrenburg MD, Rogers BB, Hladik CL, White CL III Pediatr Dev Pathol 2004 7 506-516

Honors & Awards

  • Best Doctors in America, 2013-2014
  • President, American Association of Neuropathologists
  • Best Doctors in America, 2001-2012
  • Best Doctors in America, 2009-2010
  • Best Doctors in America, 2007-2008
  • Best Doctors in America, 2005-2006
  • Best Doctors in America, 2003-2004
  • Manuscript of the Year Award, ASCP
  • Phi Beta Kappa

Professional Associations/Affiliations

  • American Society for Clinical Pathology (2001)
  • Society for Neuroscience (1990)
  • American Society for Investigative Pathology (1984)
  • The Histochemical Society (1984)
  • American Association of Neuropathologists (1983)
  • United States and Canadian Academy of Pathology (1981)