E Sally Ward Ober, Ph.D.


Endowed Title: Paul and Betty Meek-FINA Professorship in Molecular Immunology

Department: Immunology

Graduate Programs: Biomedical Engineering, Immunology, Molecular Biophysics


Undergraduate Cambridge University - England (), Natural Sciences
Graduate School Cambridge University - England (1986)


Featured Publications Legend

Featured Publications

Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model.

Patel D.A., Puig-Canto A., Challa D.K., Perez Montoyo H., Ober R.J., Ward E.S. J Immunol. 2011 2 187 1015-1022

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice.

Montoyo H.P., Vaccaro C., Hafner M., Ober R.J., Mueller W., Ward E.S. Proc Natl Acad Sci U S A. 2009 8 106 2788-2793

Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy.

Prabhat P, Gan, Z., Chao, J., Ram, S., Vaccaro, C., Gibbons, S., Ober, R.J. and Ward, E.S. Proc. Natl. Acad. Sci. USA 2007 104

Beyond Rayleigh's criterion: a resolution measure with application to single molecule microscopy.

Ram, S., Ward, E.S. and Ober, R.J. Proc. Natl. Acad. Sci. USA 2006 103 4457-4462

Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies.

Vaccaro, C., Bawdon, R., Wanjie, S., Ober, R.J., and Ward, E.S. Proc. Natl. Acad. Sci. USA 2006 103 18709-18714

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

Vaccaro, C., Zhou, J., Ober, R.J. and Ward, E.S. Nat. Biotechnol. 2005 23 1283-1288

Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level.

Ober, R.J., Martinez, C., Lai, X., Zhou, J. and Ward, E.S. Proc. Natl. Acad. Sci. USA 2004 101 11076-11081

Increasing the serum persistence of an IgG fragment by random mutagenesis.

Ghetie, V., Popov, S., Borvak, J., Radu, C., Matesoi, D., Medesan, C., Ober, R.J. and Ward, E.S. Nat. Biotechnol. 1997 15 637-640

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