Kosaku Uyeda, Ph.D.

Professor

Endowed Title: Bonnie Bell Harding Professorship in Biochemistry

Department: Biochemistry, Internal Medicine

Graduate Programs: Biological Chemistry

Education

Graduate School Oregon State University (1957)
Graduate School University of California-Berkeley (1962)

Research Interests

  • Glucose signaling pathway and its signaling mechanism in lipogenesis.
  • Long term regulation which includes transcriptional controls by hormones, nutrients and stress factors.
  • Regulation of carbohydrate metabolism and lipogenesis in various mammalian tissues.
  • Short term regulation such as allosteric controls of key enzymes in glucose metabolism and fat synthesis.

Publications

Featured Publications Legend

Featured Publications

Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP)

Sakiyamam H, Wynn, RM, Lee, WR, Fukasawa, M, Mizuguchi, H, Gardner, KH, Repa, JJ, and Uyeda,K J Biol. Chem. September 2008 283 24899-24908

Carbohydrate-response element-binding protein deletion alters substrrate utilization producing an energy-deficient liver

Burgess, SC, Iizuka, K., Jeoung, NH, Harris, RA, Kashiwaya, Y, Veech, RL, Kitazume, T, and Uyeda, K., J. Biol. Chem 2008 283 1670-1678

Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis.

Uyeda, K., and Repa, J.J. Cell Metabolism 2006 4 107-110

Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.

Iizuka, K., Miller, B., and Uyeda, K. Am. J. of Physiol. Endcrinol. Metab. 2006 291 E358-E364

Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.

Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K. Proc. Natl. Acad. Sci. USA May 2003 100(10) 5578-80

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Honors/Awards

  • William S. Middleton Award
    (1984)

Professional Associations/Affiliations

  • American Association for the Advancement of Science
  • American Chemical Society
  • American Society of Biological Chemists