Deepali Gupta, Ph.D.

Deepali Gupta, Ph.D., is an Assistant Instructor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of the Center for Hypothalamic Research. 

UT Southwestern was the first to give me an opportunity to go beyond my country's borders for science training. The collaborative clinical and basic scientific research helped integrate my basic research into the clinical settings.

Originally from India, Dr. Gupta holds a bachelor’s degree in Pharmacy from the Rajiv Gandhi Technical University in Madhya Pradesh, and a master’s degree in Pharmacology from the Birla Institute of Technology and Science in Pilani, Rajasthan. She continued her education at the Birla Institute of Technology and Science, Pilani to earn her doctorate in Neuropharmacology. She joined UT Southwestern Medical Center to conduct postdoctoral research in the biological functions and signaling of the ghrelin system under the mentorship of Jeffrey Zigman, Ph.D. 

Dr. Gupta’s research interests include understanding signaling pathways involves in endocrine disorders such as diabetes and obesity and in psychiatric behaviors such as depression. Her investigations have resulted in 44 publications in peer-reviewed journals and contributions to one book chapter. Additionally, she has presented her findings at scientific conferences in the United States and around the world.

Dr. Gupta is active in several professional organizations, including the International Society of Neurochemistry, The Obesity Society, and the American Diabetes Association, for which she serves as a member of the Membership Committee. 

During her doctoral and postdoctoral research, she served as a mentor for several high school, graduate, and postgraduate students. She also serves as an ad hoc reviewer for multiple peer-reviewed journals and as an Academic Editor for the International Journal of Endocrinology. 

Personal Note

During her free time, she enjoys cooking, listening to music, and spending time with her kids and family. She also actively volunteered at several Blood Donation Camps in India to promote people to help others. 

• Endocrine Disorders - Diabetes and Obesity
• Psychiatric Behaviors - Depression and Anxiety

Featured Publications

High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets.

Gupta D, Dowsett GKC, Mani BK, Shankar K, Osborne-Lawrence S, Metzger NP, Lam BYH, Yeo GSH, Zigman JM, Endocrinology 2021 Oct 162 10

LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue.

Shankar K, Metzger NP, Singh O, Mani BK, Osborne-Lawrence S, Varshney S, Gupta D, Ogden SB, Takemi S, Richard CP, Nandy K, Liu C, Zigman JM, Mol Metab 2021 Aug 101327

Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions.

Gupta D, Patterson AM, Osborne-Lawrence S, Bookout AL, Varshney S, Shankar K, Singh O, Metzger NP, Richard CP, Wyler SC, Elmquist JK, Zigman JM, Mol Metab 2021 May 53 101258

Acyl-ghrelin is Permissive for the Normal Counterregulatory Response to Insulin-induced Hypoglycemia.

Shankar K, Gupta D, Mani BK, Findley BG, Lord CC, Osborne-Lawrence S, Metzger NP, Pietra C, Liu C, Berglund ED, Zigman JM, Diabetes 2019 Nov

?1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.

Mani BK, Osborne-Lawrence S, Vijayaraghavan P, Hepler C, Zigman JM J. Clin. Invest. 2016 Sep 126 9 3467-3478

A novel 5HT3 antagonist 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide) prevents diabetes-induced depressive phenotypes in mice: Modulation of serotonergic system.

Gupta D, Thangaraj D, Radhakrishnan M, Behav Brain Res 2016 Jan 297 41-50

Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice.

Gupta D, Radhakrishnan M, Kurhe Y, Steroids 2015 Apr 96 95-102

Ondansetron, a 5HT3 receptor antagonist reverses depression and anxiety-like behavior in streptozotocin-induced diabetic mice: possible implication of serotonergic system.

Gupta D, Radhakrishnan M, Kurhe Y, Eur J Pharmacol 2014 Dec 744 59-66

Insulin reverses anxiety-like behavior evoked by streptozotocin-induced diabetes in mice.

Gupta D, Radhakrishnan M, Kurhe Y, Metab Brain Dis 2014 Sep 29 3 737-46

Antidepressant effects of insulin in streptozotocin induced diabetic mice: Modulation of brain serotonin system.

Gupta D, Kurhe Y, Radhakrishnan M, Physiol Behav 2014 Apr 129 73-8

 Featured Books

Antidepressant Therapy for Depression: An Update. Understanding Depression

Gupta D, Radhakrishnan M. (2018). Singapore, Springer

• Postgraduate Travel Award for 14th Meeting on Asian-Pacific Society for Neurochemistry, Malaysia
  Asian-Pacific Society for Neurochemistry (2016)
• ISN travel Award for 25th ISN-APSN Biennial Meeting in Cairns, Australia
  International Society of Neurochemistry (2015)
• Travel Award for 21st World Congress on Parkinson Disease & Related Disorders
  International Association of Parkinson Disease & Related Disorders (IAPRD), Milan, Italy (2015)
• Travel Award, for AAPS, Student Chapter, Singapore
  Department of Biotechnology, Government of India (2015)
• Travel Award for 15th International Conference on Pharmacy and Pharmacology, World Academy of Science Engineering and Technology, London, UK
  Department of Science and Technology, Government of India (2014)
• University Grant Commission India-Basic Scientific Research Fellowship
  Department of Biotechnology, India (2012-2015)
• Young scientist and Best Poster Award
  Pharma-next Conference, India (2012)
• Sir, Ratan TATA Scholarship for Graduate Students
  (2006-2008)

• International Brain Research Organization (IBRO) (2016-2017)
• International Society for Neurochemistry (ISN) (2015)
• The American Diabetes Association (2019)
• The Endocrine Society (2019)
• The Obesity Society (2019-2021)