Stephen Turley, Ph.D.

Professor

Department: Internal Medicine

Biography

Dr. Turley is research professor in the Department of Internal Medicine. He received his Ph.D. from the Australian National University and then completed three years of postdoctoral training in the Department of Internal Medicine at the University of Texas Health Science Center in Dallas in 1979.

Dr. Turley’s research interests focus mainly on three areas of cholesterol metabolism. One of these relates to the mechanisms that regulate sterol absorption. The second area is the regulation and quantitative importance of the two main pathways by which the liver converts cholesterol to bile acids. These studies are utilizing mice deficient in either cholesterol 7alpha-hydroxylase or sterol 27-hydroxylase. The third area of interest relates to the regulation of cholesterol metabolism in the brain during fetal and neonatal development. Dr. Turley gives frequent lectures and has published extensively on these topics.

Education

Undergraduate University of New England (1972)
Graduate School Australian National University - Australia (1976)

Research Interests

  • bile acid metabolism
  • cholesterol metabolism
  • gallstone disease
  • heart disease
  • sterol absorption

Publications

Featured Publications Legend

Featured Publications

Role of Niemann-Pick C1-like 1 (NPC1L1) in intestinal sterol absorption

Turley, S.D. J Clin Lipidol March 2008 2 S20-S28

Lysosomal unesterified cholesterol content correlates with liver cell death in murine Niemann-Pick type C disease

Beltroy, E.P., Liu, B., Dietschy, J.M., Turley, S.D. J Lipid Res Summer 2007 48 869-881

Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption

Repa, J.J., Turley, S.D., Quan, G. and Dietschy, J.M. J. Lipid Res. 2005 46 779-789

Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse

Garver, W.S., Xie, C., Repa, J.J., Turley, S.D., Dietschy, J,M. J. Lipid Res. 2005 46 1745-1754

Cholesterol accumulation and liver cell death in the mouse with Niemann-Pick type C disease

Beltroy, E.P., Richardson, J.A., Horton, J.D., Turley, S.D., Dietschy, J.M. Hepatology 2005 42 886-893

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