The torsin-family AAA+ protein OOC-5 contains a critical disulfide adjacent to Sensor-II that couples redox state to nucleotide binding.
Zhu L, Wrabl JO, Hayashi AP, Rose LS, Thomas PJ Mol Biol Cell August 2008 19(8) 3599-612
Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3.
Dorwart MR, Shcheynikov N, Baker JM, Forman-Kay JD, Muallem S, Thomas PJ J Biol Chem March 2008 283(13) 8711-22
Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation.
Pissarra LS, Farinha CM, Xu Z, Schmidt A, Thibodeau PH, Cai Z, Thomas PJ, Sheppard DN, Amaral MD Chem Biol January 2008 15(1) 62-9
Building an understanding of cystic fibrosis on the foundation of ABC transporter structures.
Mendoza JL, Thomas PJ J Bioenerg Biomembr December 2007 39(5-6) 499-505
CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices.
Baker JM, Hudson RP, Kanelis V, Choy WY, Thibodeau PH, Thomas PJ, Forman-Kay JD Nat Struct Mol Biol August 2007 14(8) 738-45
A protein sequence that can encode native structure by disfavoring alternate conformations.
Wigley WC, Corboy MJ, Cutler TD, Thibodeau PH, Oldan J, Lee MG, Rizo J, Hunt JF, Thomas PJ Nat Struct Biol May 2002 9(5) 381-8
Cooperative, ATP-dependent association of the nucleotide binding cassettes during
Moody JE, Millen L, Binns D, Hunt JF, Thomas PJ J Biol Chem April 2002 277 21111-4
Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis.
Choi JY, Muallem D, Kiselyov K, Lee MG, Thomas PJ, Muallem S Nature March 2001 410(6824) 94-7
Protein solubility and folding monitored in vivo by structural complementation of a genetic marker protein.
Wigley WC, Stidham RD, Smith NM, Hunt JF, Thomas PJ Nat Biotechnol February 2001 19(2) 131-6
Dynamic association of proteasomal machinery with the centrosome.
Wigley WC, Fabunmi RP, Lee MG, Marino CR, Muallem S, DeMartino GN, Thomas PJ J Cell Biol May 1999 145(3) 481-90