Dwain Thiele, M.D.

Sr Assoc Dean Strategic Development

Professor

Endowed Title: Jan and Henri Bromberg Chair in Internal Medicine

Department: Office of the Dean - Southwestern Medical School, Internal Medicine

Graduate Programs: Immunology

Biography

Dr. Thiele joined the Department of Internal Medicine in 1983, and the Graduate Program in Immunology in the Graduate School of Biomedical Sciences in 1986. He served as Chief of Hepatology from 1998-2005, Interim Chief of the Division of Digestive and Liver Diseases from 2002-2005,Vice Chair for Financial Affairs, Department of Internal Medicine from 2005-2010 and as Interim Chair, Department of Internal Medicine, 2009-2010 before assuming his current position as a Senior Associate Dean. Dr. Thiele has broad interests in clinical hepatology, with special interests in acute viral hepatitis, autoimmune hepatitis and acute hepatitis of unknown etiology. Research conducted in Dr. Thiele’s laboratory focuses on delineating mechanisms of cytotoxic lymphocyte activation, differentiation and effector function, and exploring the role of these immune effector mechanisms in clearance of viral infections from the liver.

Education

Medical School Baylor College of Medicine (1977)
Residency Duke University School of Medicine (1980), Internal Medicine
Fellowship University of Texas Southwestern Medical School (1983), Gastroenterology & Liver Diseases

Specialty Areas

Clinical Interests

  • Abnormal Liver Function
  • Ascites
  • Autoimmune Hepatitis
  • Drug Induced Liver Disease
  • Elevated Transaminase
  • Fatty Liver
  • Hepatitis B
  • Hepatitis C
  • Liver Cancer (Hepatocellular Carcinoma)
  • Liver Cancer, Cysts, Masses & Tumors
  • Liver Cirrhosis
  • Liver Disease in the Pregnant Patient
  • Primary Biliary Cirrhosis (PBC)
  • Primary Sclerosing Cholangitis (PSC)
  • Viral Hepatitis

Research Interests

  • Antiviral immune responses
  • Cytotoxic lymphocyte function
  • Transplantation immunology

Publications

Featured Publications Legend

Featured Publications

The role of serpinB9 / serine protease inhibitor 6 in preventing granzyme B dependent hepatotoxicity

Stout-Delgado HW, Y Getachew, TE Rogers, BC Miller and DL Thiele Hepatology 2007 45 In Press

Intrahepatic Lymphocyte Expression of Dipeptidyl Peptidase I Processed Granzyme B and Perforin Induces Hepatocyte Expression of Serine Proteinase Inhibitor 6 (Serpinb9/SPI-6).

74. Stout-Delgado HW, Y Getachew, BC Miller and DL Thiele J. Immunol. 2007 179 6561-6567

Anti-viral cytokines induce hepatic expression of the granzyme B inhibitors proteinase inhibitor 9 and serine proteinase inhibitor 6

Barrie MB, HW Stout, MS Abougergi, BC Miller and DL Thiele J Immunol 2004 172 6453-6459

Fas and TNFR1 but not cytolytic granule dependent mechanisms mediate clearance of liver adenovirus infection

Abougergi MC, SJ Gidner, DK Spady, BC Miller and DL Thiele Hepatology 2004 41 97-102

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB and Thiele DL Proc Natl Acad Sci U S A 2003 100 6221-6226

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Honors/Awards

  • American Association of Physicians
    (2004)
  • Teacher of the Year, UT Southwestern Gastroenterology Training Program
    (2000)
  • American Society for Clinical Investigation
    (1997)
  • Best Doctors in America
    (1996)
  • Teacher of the Year, UT Southwestern Gastroenterology Training Program
    (1994)

Professional Associations/Affiliations

  • American Association for Immunologists
  • American Association for the Study of Liver Diseases
  • American Gastroenterological Association