Dr. Taurog has been a faculty member in the Division of Rheumatic Diseases at UT Southwestern since 1986. Since joining the faculty he has served as attending physician in rheumatology and internal medicine at Parkland Memorial Hospital. From 1980 to 1986 he was a faculty member in rheumatology and internal medicine at the University of Minnesota in Minneapolis.
The goal of Dr. Taurog's research has been to understand the molecular basis for the association of the rheumatic disease called ankylosing spondylitis with the major histocompatibility allele HLA-B27. This MHC class I allele is found in 7 percent of the U.S. population, but in over 90 percent of individuals with ankylosing spondylitis. Of individuals with B27, it is estimated that up to 13 percent will develop ankylosing spondylitis or a related form of spondyloarthritis.
Dr. Taurog's efforts largely involve the study of rats transgenic for HLA-B27 and its associated light chain, beta-2-microglobulin. The rats develop a spontaneous arthritis and spondylitis that in many ways mimics the spectrum of the human spondyloarthropathies.
We have used a variety of cellular, genetic, biochemical and microbiological approaches have been used to try to understand the role of the B27 molecule in the pathogenesis of this experimental disorder.
- Medical School
- UT Southwestern Medical Center (1974)
- Harvard Medical School/Brigham & Women's Hospital (1975), Int. Medicine
- Harvard Medical School/Brigham & Women's Hospital (1976), Int. Medicine
- National Institutes of Health-Research (1980), Immunology/rheumatology
- Role of HLA-B27 in Spondyloarthritis
- Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders.
- Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD Cell 1990 Nov 63 5 1099-112
- Loss of bone strength in HLA-B27 transgenic rats is characterized by a high bone turnover and is mainly osteoclast-driven.
- Rauner M, Thiele S, Fert I, Araujo LM, Layh-Schmitt G, Colbert RA, Hofbauer C, Bernhardt R, Bürki A, Schwiedrzik J, Zysset PK, Pietschmann P, Taurog JD, Breban M, Hofbauer LC Bone 2015 Mar 75 183-191
- Role of PPM1A and anti-PPM1A Autoantibodies in Ankylosing Spondylitis.
- Kim YG, Sohn DH, Zhao X, Sokolove J, Lindstrom TM, Yoo B, Lee CK, Reveille JD, Taurog JD, Robinson WH Arthritis & rheumatology (Hoboken, N.J.) 2014 Jun
- Reverse interferon signature is characteristic of antigen-presenting cells in human and rat spondyloarthritis.
- Fert I, Cagnard N, Glatigny S, Letourneur F, Jacques S, Smith JA, Colbert RA, Taurog JD, Chiocchia G, Araujo LM, Breban M Arthritis & rheumatology (Hoboken, N.J.) 2014 Apr 66 4 841-51
- HLA-B27 and Human ß2-Microglobulin Affect the Gut Microbiota of Transgenic Rats.
- Lin P, Bach M, Asquith M, Lee AY, Akileswaran L, Stauffer P, Davin S, Pan Y, Cambronne ED, Dorris M, Debelius JW, Lauber CL, Ackermann G, Baeza YV, Gill T, Knight R, Colbert RA, Taurog JD, Van Gelder RN, Rosenbaum JT PLoS ONE 2014 9 8 e105684
- Relationship between inflammation, bone destruction, and osteoproliferation in spondyloarthritis in HLA-B27/Huß2m transgenic rats.
- van Duivenvoorde LM, Dorris ML, Satumtira N, van Tok MN, Redlich K, Tak PP, Taurog JD, Baeten DL Arthritis and rheumatism 2012 Jun
- Autoimmune epididymo-orchitis is essential to the pathogenesis of male-specific spondyloarthritis in HLA-B27 transgenic rats.
- Taurog JD, Rival C, van Duivenvoorde LM, Satumtira N, Dorris ML, Sun M, Shelton JM, Richardson JA, Hamra FK, Hammer RE, Tung KS Arthritis and rheumatism 2012 Apr
- Spondylarthritis in HLA-B27/human beta2-microglobulin-transgenic rats is not prevented by lack of CD8.
- Taurog JD, Dorris ML, Satumtira N, Tran TM, Sharma R, Dressel R, van den Brandt J, Reichardt HM Arthritis Rheum. 2009 Jul 60 7 1977-84
- Additional human beta2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats.
- Tran TM, Dorris ML, Satumtira N, Richardson JA, Hammer RE, Shang J, Taurog JD Arthritis Rheum. 2006 Apr 54 4 1317-27
- The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.
- Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernández-Sueiro JL, Balish E, Hammer RE J. Exp. Med. 1994 Dec 180 6 2359-64
Honors & Awards
- Master of the American College of Rheumatology
- Glenn Clark Lectureship
University of Tennessee, Memphis (2008)
- William M. & Gatha Burnett Professorship for Arthritis Research
UT Southwestern Medical Center (1997)
- Kroc Lectureship
University of Michigan (1993)
- Carol-Nachman Prize for Rheumatology
State Capital of Wiesbaden, Germany (1992)
- Rheumatologist of the Year
Abstract Rhumato (French Journal) (1991)
- American Society for Clinical Investigation (1991)
- American Association of Immunologists (1980)
- American College of Rheumatology (1980)