David Hsieh, M.D. Titles and Appointments Associate Professor School Medical School Department Internal Medicine You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography David Hsieh, M.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Hematology and Oncology. Originally from Tucson, Arizona, Dr. Hsieh earned his medical degree at the University of Arizona College of Medicine. He completed internal medicine residency training at Mount Auburn Hospital in Cambridge, Massachusetts. He then completed advanced training through a fellowship in hematology and oncology at UT Southwestern Medical Center. A Diplomate of the American Board of Internal Medicine in medical oncology, Dr. Hsieh joined the UT Southwestern faculty in 2019. Dr. Hsieh leads clinical trials testing new drugs for liver cancers including hepatocellular carcinoma and cholangiocarcinomas. His other research interests include translational studies to understand mechanisms behind the variable effectiveness of cancer therapies between patients and the development of treatment biomarkers. He also researches processes, policies, and biases in scientific research and medicine. Dr. Hsieh's clinical interests include hepatocellular carcinoma and biliary tract cancers including cholangiocarcinomas and gall bladder cancers. Dr. Hsieh's awards and honors include an Early Career Investigator Award from the Cancer Prevention and Research Institute of Texas. Education Medical School University of Arizona College of Medicine-Phoenix (2013) Residency Mount Auburn Hospital (2016), Internal Medicine Fellowship UT Southwestern Medical Center (2019), Hematology Oncology Research Interest Cholangiocarcinoma Hepatocellular carcinoma Immunotherapy Liver cancer Mechanisms of drug resistance Predictive biomarkers Publications Featured Publications Dual TIGIT and PD-1 blockade with domvanalimab plus zimberelimab in hepatocellular carcinoma refractory to anti-PD-1 therapies: the phase 2 LIVERTI trial. Hsiehchen D, Kainthla R, Kline H, Siglinsky E, Ahn C, Zhu H, Nat Commun 2025 Jul 16 1 5819 Complete Response to Immunotherapy in Patients With Hepatocellular Carcinoma. Lim M, Espinoza M, Huang YH, Franses J, Zhu H, Hsiehchen D, JAMA Netw Open 2025 Feb 8 2 e2461735 Mutation burden and anti-PD-1 outcomes are not universally associated with immune cell infiltration or lymphoid activation. Hsiehchen D, Elliott A, Xiu J, Seeber A, El-Deiry W, Antonarakis ES, Graff SL, Hall MJ, Borghaei H, Hoon DSB, Liu SV, Ma PC, McKay RR, Wise-Draper T, Marshall J, Sledge GW, Spetzler D, Zhu H, Cancer Cell 2024 Nov The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial. Hsiehchen D, Beg MS, Kainthla R, Lohrey J, Kazmi SM, Khosama L, Maxwell MC, Kline H, Katz C, Hassan A, Kubota N, Siglinsky E, Pillai AK, Youssoufian H, Mockbee C, Culm K, Uhlik M, Benjamin L, Brekken RA, Ahn C, Singal AG, Zhu H, Hoshida Y, Yopp AC, Nat Commun 2024 Mar 15 1 2178 Tissue-specific thresholds of mutation burden associated with anti-PD-1/L1 therapy benefit and prognosis in microsatellite-stable cancers. Muquith M, Espinoza M, Elliott A, Xiu J, Seeber A, El-Deiry W, Antonarakis ES, Graff SL, Hall MJ, Borghaei H, Hoon DSB, Liu SV, Ma PC, McKay RR, Wise-Draper T, Marshall J, Sledge GW, Spetzler D, Zhu H, Hsiehchen D, Nat Cancer 2024 Mar Landscape and Saturation Analysis of Mutations Associated With Race in Cancer Genomes by Clinical Sequencing. Muquith M, Hsiehchen D, Oncologist 2024 Mar 29 3 219-226 Lengthy and Variable Delays in Oncology Drug Coverage Determination. Haque W, Rana I, Zahid S, Hsiehchen D, JAMA Oncol 2023 Dec 9 12 1728-1729 Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial. Qin S, Chen M, Cheng AL, Kaseb AO, Kudo M, Lee HC, Yopp AC, Zhou J, Wang L, Wen X, Heo J, Tak WY, Nakamura S, Numata K, Uguen T, Hsiehchen D, Cha E, Hack SP, Lian Q, Ma N, Spahn JH, Wang Y, Wu C, Chow PKH, Lancet 2023 Oct Treatment Beyond Progression After Anti-PD-1 Blockade in Hepatocellular Carcinoma. Lim M, Muquith M, Miramontes B, Espinoza M, Hsiehchen D, Cancer Res Commun 2023 Sep 3 9 1912-1916 Salvage Ipilimumab plus Nivolumab after Anti-PD-1/PD-L1 Therapy in Advanced Hepatocellular Carcinoma. Alden SL, Lim M, Kao C, Shu D, Singal AG, Noonan A, Griffith P, Baretti M, Ho WJ, Kamel I, Yarchoan M, Hsiehchen D, Cancer Res Commun 2023 Jul 3 7 1312-1317 Results 1-10 of 34 1 2 3 4 Next Last Honors & Awards CPRIT Early Clinical Investigator Award (2020) ASH Research Training Award for Fellows (2018)
