Ram Madabhushi, Ph.D. Titles and Appointments Associate Professor Endowed Title Thomas O. Hicks Scholar in Medical Research Schools Medical School | Graduate School Departments Psychiatry | Cell Biology | Neuroscience Graduate Programs Neuroscience Biography Dr. Madabhushi graduated with a bachleor's degree in Biology from the University of Bridgeport in Connecticut. He obtained his PhD in Molecular Biology from Weill Graduate School of Cornell University in New York, where he studied how cytokinesis is coordinated with chromosome segregation in the bacterial model organism, E. coli. Subsequently, Dr. Madabhushi conducted his postdoctoral research at the Picower Institute for Learning and Memory at MIT, where he studied mechanisms governing genomic stability and activity-dependent gene expression in neurons. Dr. Madabhushi joined the faculty in the Department of Psychiatry in 2017. Education Undergraduate University of Bridgeport (2003), Biology Graduate School Cornell University Medical Col (2010), Molecular & Cell Biology Research Interest Chromatin dynamics and epigenetic regulation of activity-dependent gene expression The role of genomic instability in neurological disorders and cancer Publications Featured Publications The Roles of DNA Topoisomerase II? in Transcription. Madabhushi R Int J Mol Sci 2018 Jun 19 7 Emerging themes in neuronal activity-dependent gene expression. Madabhushi R, Kim TK Mol. Cell. Neurosci. 2017 Dec Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes. Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH Cell 2015 Jun 161 7 1592-605 DNA damage and its links to neurodegeneration. Madabhushi R, Pan L, Tsai LH Neuron 2014 Jul 83 2 266-82 SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Dobbin MM, Madabhushi R, Pan L, Chen Y, Kim D, Gao J, Ahanonu B, Pao PC, Qiu Y, Zhao Y, Tsai LH Nat. Neurosci. 2013 Aug 16 8 1008-15 RNAPII and DNA supercoiling regulate cohesin engagement in neurons. Crewe M, Delint-Ramirez I, Halawa O, Heady L, Madabhushi R, Nucleic Acids Res 2026 Jun 54 11 The heat shock transcription factor, HSF1, stimulates the catalytic engagement of topoisomerase IIβ over topoisomerase IIα. Konada L, Catley TE, Heady L, Crewe M, Delint-Ramirez I, Wiggins L, Fajardo Briseno S, Bhat MY, Segev A, Pyne ALB, Madabhushi R, Mol Cell 2026 Jun DNA damage and its links to neuronal aging and degeneration. Delint-Ramirez I, Madabhushi R, Neuron 2025 Jan 113 1 7-28 NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4. Delint-Ramirez I, Madabhushi R, Mol Cell 2023 Apr 83 8 1208-1209 Calcineurin dephosphorylates topoisomerase II? and regulates the formation of neuronal-activity-induced DNA breaks. Delint-Ramirez I, Konada L, Heady L, Rueda R, Jacome ASV, Marlin E, Marchioni C, Segev A, Kritskiy O, Yamakawa S, Reiter AH, Tsai LH, Madabhushi R, Mol Cell 2022 Oct 82 20 3794-3809.e8 Results 1-10 of 15 1 2 Next Last
