William Snell, Ph.D.


Department: Cell Biology

Graduate Programs: Cell Regulation, Integrative Biology


Graduate School Yale University (1969), Cell Biology
Graduate School Yale University (1975), Cell Biology

Research Interests

  • Cellular and molecular mechanisms of cell-cell fusion
  • Cilium-generated signaling and intraflagellar transport
  • Malaria vaccines
  • Regulation of ciliary membrane protein composition by cilium-generated signaling
  • The biology of cilia and flagella


Featured Publications Legend

Featured Publications

Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates.

Ning J, Otto TD, Pfander C, Schwach F, Brochet M, Bushell E, Goulding D, Sanders M, Lefebvre PA, Pei J, Grishin NV, Vanderlaan G, Billker O, Snell WJ Genes Dev. 2013 May 27 10 1198-215

Regulated trafficking of a membrane protein to Chlamydomonas flagella does not require IFT and is directed by cytoplasmic microtubules.

*Belzile, B, *Hernandez-Lara, C I, *Wang, Q, and Snell, W J (*Authors contributed equally to this work.) Curr. Biol. 2013 000 In Press: See Snell Lab website for pdf file of Author Approved Manuscript 0000

A molecular reporter of organelle size: Activation loop phosphorylation of a protein kinase dynamically reports flagellar length.

Cao, M, Meng, D, Wang, L, Bei, S, *Snell, WJ and *Pan, J (*Co-corresponding authors) P. N. A. S. 2013 000 In Press

Development. Plant gametes do fertilization with a twist.

Snell WJ Science 2012 Nov 338 6110 1038-9

Evolutionarily conserved Delta(25(27))-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii.

Miller MB, Haubrich BA, Wang Q, Snell WJ, Nes WD J. Lipid Res. 2012 Aug 53 8 1636-45

The phosphorylation state of an aurora-like kinase marks the length of growing flagella in Chlamydomonas.

Luo M, Cao M, Kan Y, Li G, Snell W, Pan J Curr. Biol. 2011 Apr 21 7 586-91

The ciliary membrane.

Rohatgi R, Snell WJ Curr. Opin. Cell Biol. 2010 Aug 22 4 541-6

Membrane fusion triggers rapid degradation of two gamete-specific, fusion-essential proteins in a membrane block to polygamy in Chlamydomonas.

Liu Y, Misamore MJ, Snell WJ Development 2010 May 137 9 1473-81

Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm.

Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P Mol. Reprod. Dev. 2009 Dec 76 12 1188-99

SnapShot: Intraflagellar transport.

Cole DG, Snell WJ Cell 2009 May 137 4 784-784.e1

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