A. Dean Sherry, PhD, is Professor of Chemistry at the University of Texas at Dallas and Professor of Radiology at UT Southwestern Medical Center in Dallas. He holds the Cecil & Ida Green Distinguished Chair in Systems Biology at UT Dallas and serves as Director of the Advanced Imaging Research Center at UT Southwestern. He was recognized for his outstanding achievements in chemistry by winning the Doherty Award from the DFW Section of the American Chemical Society in 1990, was honored by receiving the Chancellor’s Outstanding Teaching Award at UT-Dallas in 1994, was elected a Fellow of the ISMRM in 2011, and won the Gold Medal from the World Molecular Imaging Society in 2013. In 2015, he was elected a Fellow of the World Molecular Imaging Society and won the Gold Medal from the ISMRM for his work on MRI contrast agents. Dr. Sherry's research interests include applications of 2H and 13C stable isotopes as tracers of metabolism in vivo and the development of novel molecular imaging agents for MRI. He has been actively involved with the development of 13C isotopomer methods to measure flux through complex metabolic pathways in vivo and continues to apply those techniques to the analysis of liver and heart metabolism in small animal models and humans. Together with other scientists in the AIRC, he is now developing hyperpolarized 13C tracers for imaging metabolism in real time in isolated organs, intact animals and humans. He has also been active in the development of gadolinium complexes as MRI contrast agents since the early 1980s and is now working on the next generation smart agents that respond to biological indices such as pH and metal ions important in cellular metabolism. His group recently reported a novel Zn2+ sensor for monitoring beta-cell function in the pancreas in vivo by MRI. He was first to report the use of europium complexes as PARACEST agents and maintains an active interest in developing novel paraCEST reporter systems for molecular imaging. He served as Deputy Editor for Magnetic Resonance in Medicine from 2010 to 2014 and currently serves as Associate Editor of Contrast Media & Molecular Imaging.
- Wisconsin State University , Chemistry
- Graduate School
- Wisconsin State University (1971), Chemistry
- Stable isotope tracers for imaging metabolism in vivo, responsive MR imaging agents for detecting changes in biology or physiology in vivo, hyperpolarized 13C metabolite probes for imaging metabolism in vivo
- Kinetic modeling and constrained reconstruction of hyperpolarized 1-13C-pyruvate offers improved metabolic imaging of tumors.
- Bankson JA, Walker CM, Ramirez MS, Stefan W, Fuentes D, Merritt ME, Lee J, Sandulache VC, Chen Y, Phan L, Chou PC, Rao A, Yeung SJ, Lee MH, Schellingerhout D, Conrad CA, Malloy C, Sherry AD, Lai SY, Hazle JD Cancer Res. 2015 Sep
- (31) P-MRS of healthy human brain: ATP synthesis, metabolite concentrations, pH, and T1 relaxation times.
- Ren J, Sherry AD, Malloy CR NMR Biomed 2015 Sep
- pH imaging of mouse kidneys in vivo using a frequency-dependent paraCEST agent.
- Wu Y, Zhang S, Soesbe TC, Yu J, Vinogradov E, Lenkinski RE, Sherry AD Magn Reson Med 2015 Jul
- [(68) Ga]-HP-DO3A-nitroimidazole: a promising agent for PET detection of tumor hypoxia.
- Wu Y, Hao G, Ramezani S, Saha D, Zhao D, Sun X, Sherry AD Contrast Media Mol Imaging 2015 Jun
- A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.
- Wang X, Wu Y, Soesbe TC, Yu J, Zhao P, Kiefer GE, Sherry AD Angew. Chem. Int. Ed. Engl. 2015 Jun
- Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE).
- Moreno KX, Nasr K, Milne M, Sherry AD, Goux WJ J. Magn. Reson. 2015 May 257 15-23
- A simple approach to evaluate the kinetic rate constant for ATP synthesis in resting human skeletal muscle at 7 T.
- Ren J, Sherry AD, Malloy CR NMR Biomed 2015 May
- Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.
- Burgess SC, Merritt ME, Jones JG, Browning JD, Sherry AD, Malloy CR Nat. Med. 2015 Feb 21 2 108-9
- A Molecular Platform for Design and Synthesis of Targeted Dual-modality Imaging Probes.
- Kumar A, Zhang S, Hao G, Hassan G, Ramezani S, Lo ST, Sagiyama K, Takahashi M, Sherry AD, Oz OK, Kovács Z, Sun X Bioconjug. Chem. 2015 Jan
- Hyperpolarized (15)N-pyridine Derivatives as pH-Sensitive MRI Agents.
- Jiang W, Lumata L, Chen W, Zhang S, Kovacs Z, Sherry AD, Khemtong C Sci Rep 2015 5 9104
Honors & Awards
- Fellow, World Molecular Imaging Society
Fellow of the WMIS (2015)
- Gold Medal Award, International Society for Magnetic Resonance in Medicine
Gold Medal Award (2015)
- Gold Medal Award from the World Molecular Imaging Society
Gold Medal Award (2013)
- Fellow, International Society for Magnetic Resonance in Medicine
Fellow of the ISMRM (2011)
- Director, Advanced Imaging Research Center
UT Southwestern (2005)
- Distinguished Chair in Systems Biology
UT Dallas (2005)
- Cecil & Ida Green Honors Chair in Chemistry
UT Dallas (2002-2005)
- UT Dallas Chancellor's Council Outstanding Teaching Award
- WT Doherty Award
American Chemical Society (1990)
- NIH Senior Fellow
- NIH Postdoctoral Fellow