A. Dean Sherry, PhD, is Professor of Chemistry at the University of Texas at Dallas and Professor of Radiology at UT Southwestern Medical Center in Dallas. He holds the Cecil & Ida Green Distinguished Chair in Systems Biology at UT Dallas and serves as Director of the Advanced Imaging Research Center at UT Southwestern. He was recognized for his outstanding achievements in chemistry by winning the Doherty Award from the DFW Section of the American Chemical Society in 1990, was honored by receiving the Chancellor’s Outstanding Teaching Award at UT-Dallas in 1994, was elected as a Fellow of the ISMRM in 2011, and won the Gold Medal from the World Molecular Imaging Society in 2013. Dr. Sherry research interests include applications of 2H and 13C stable isotopes as tracers of metabolism in vivo and the development of novel molecular imaging agents for MRI. He has been actively involved with the development of 13C isotopomer methods to measure flux through complex metabolic pathways in vivo and continues to apply those techniques to the analysis of liver and heart metabolism in small animal models and humans. Together with other scientists in the AIRC, he is now developing hyperpolarized 13C tracers for imaging metabolism in real time in isolated organs, intact animals and humans. He has also been active in the development of gadolinium complexes as MRI contrast agents since the early 1980s and is now working on the next generation smart agents that respond to biological indices such as pH and metal ions important in cellular metabolism. His group recently reported a novel Zn2+ sensor for monitoring beta-cell function in the pancreas in vivo by MRI. He was first to report the use of europium complexes as PARACEST agents and maintains an active interest in developing novel paraCEST reporter systems for molecular imaging. He served as Deputy Editor for Magnetic Resonance in Medicine from 2010 to 2014 and currently serves as Associate Editor of Contrast Media & Molecular Imaging. He received the Gold Medal Award from the World Molecular Imaging Society in 2013.
- Wisconsin State University , Chemistry
- Graduate School
- Wisconsin State University (1971), Chemistry
- Stable isotope tracers for imaging metabolism in vivo, responsive MR imaging agents for detecting changes in biology or physiology in vivo.
- Propionate stimulates pyruvate oxidation in the presence of acetate.
- Purmal C, Kucejova B, Sherry AD, Burgess SC, Malloy CR, Merritt ME Am. J. Physiol. Heart Circ. Physiol. 2014 Oct 307 8 H1134-41
- Interaction between the Pentose Phosphate Pathway and Gluconeogenesis from Glycerol in the Liver.
- Jin ES, Sherry AD, Malloy CR J. Biol. Chem. 2014 Oct
- The Ratio of Acetate-to-Glucose Oxidation in Astrocytes from a Single (13) C NMR Spectrum of Cerebral Cortex.
- Marin-Valencia I, Hooshyar AM, Pichumani K, Sherry DA, Malloy CR J. Neurochem. 2014 Sep
- Hyperpolarized (13) C NMR detects rapid drug-induced changes in cardiac metabolism.
- Khemtong C, Carpenter NR, Lumata LL, Merritt ME, Moreno KX, Kovacs Z, Malloy CR, Sherry AD Magn Reson Med 2014 Aug
- Redox- and hypoxia-responsive MRI contrast agents.
- Do QN, Ratnakar JS, Kovács Z, Sherry AD ChemMedChem 2014 Jun 9 6 1116-29
- Exchange kinetics by inversion transfer: Integrated analysis of the phosphorus metabolite kinetic exchanges in resting human skeletal muscle at 7 T.
- Ren J, Yang B, Sherry AD, Malloy CR Magn Reson Med 2014 Apr
- In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma.
- Sagiyama K, Mashimo T, Togao O, Vemireddy V, Hatanpaa KJ, Maher EA, Mickey BE, Pan E, Sherry AD, Bachoo RM, Takahashi M Proc. Natl. Acad. Sci. U.S.A. 2014 Mar 111 12 4542-7
- Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.
- Yang C, Harrison C, Jin ES, Chuang DT, Sherry AD, Malloy CR, Merritt ME, Deberardinis RJ J. Biol. Chem. 2014 Jan
- Maximizing T2 -exchange in Dy(3+) DOTA-(amide)X chelates: Fine-tuning the water molecule exchange rate for enhanced T2 contrast in MRI.
- Soesbe TC, Ratnakar SJ, Milne M, Zhang S, Do QN, Kovacs Z, Sherry AD Magn Reson Med 2014 Jan
- GdDO3NI, a nitroimidazole-based T 1 MRI contrast agent for imaging tumor hypoxia in vivo.
- Gulaka PK, Rojas-Quijano F, Kovacs Z, Mason RP, Sherry AD, Kodibagkar VD J. Biol. Inorg. Chem. 2013 Nov
Honors & Awards
- Gold Medal Award from the World Molecular Imaging Society
Gold Medal Award (2013)
- Fellow, International Society for Magnetic Resonance in Medicine
Fellow of the ISMRM (2011)
- Director, Advanced Imaging Research Center
UT Southwestern (2005)
- Distinguished Chair in Systems Biology
UT Dallas (2005)
- Cecil & Ida Green Honors Chair in Chemistry
UT Dallas (2002)
- UT Dallas Chancellor's Council Outstanding Teaching Award
- WT Doherty Award
American Chemical Society (1990)
- NIH Senior Fellow
- NIH Postdoctoral Fellow