Jerry Shay, Ph.D.

Jerry W. Shay Professor

EDUCATION/TRAINING

 The University of Texas at Austin, BA, Zoology/ Cell Biology, 1966

The University of Kansas at Lawrence, MA, Cell Biol. & Physiol.Mol. Cell., 1968

The University of Colorado at Boulder, PhD, Develop. Biology, 1972-1975

 

POSITIONS AND EMPLOYMENT

1975-1993 Assistant/Associate Professor, Department of Cell Biology/Neuroscience, UT Southwestern

1993- Professor, Department of Cell Biology, UT Southwestern, Southland Financial Corporation Distinguished Chair in Geriatric Research

2002- Associate Director, Education and Training, UT Southwestern Harold Simmons Comprehensive Cancer Center

PANELS

1990-1994 Member, NIH Study Section on Mammalian Genetics

1995-1997 Susan G. Komen Breast Cancer Foundation Research Grant Committee

1996- present Mary Kay Ash Foundation, Chairman, Scientific Review Committee

 

SCIENTIFIC ADVISORY BOARDS/CONSULTATIONS

2002- present Reata Pharmaceutical, Dallas, TX (SAB)

2012- present KAU University, Center for Excellence in Medical Genetics Research, Jeddah Saudi Arabia (Chair, SAB)

 

 

EDITORIAL BOARDS

In Vitro, Cellular and Developmental Biology; Methods in Cell Science; Differentiation; International Journal of Molecular Medicine and Oncology; Experimental Gerontology; Antiaging Research; Mechanisms of Aging and Development: Aging Research Reviews; J. Clinical Pathology; Neoplasia; J. National Cancer Institute; Clinical Cancer Research; J. Regenerative Medicine.

 

AWARDS

1978-1983 NIH Research Career Development Award

1995-1997 AlliedSignal Award for Research on Aging

1997 Institute for Scientific Research - Most highly cited researchers

1996-2003 Ellison Medical Foundation Senior Scholar

2001 American Aging Association, Hayflick Award

2005-2008 Ted Nash Award

 

CURRENT INTERNAL COMMITTEES

1996- Senior Leadership Committee UT Southwestern Simmons Comprehensive Cancer Center

1997-present Executive Committee UTSW/MD Anderson Lung Cancer SPORE

 

 

 

 

US PATENTS

#5,489,508 Issue date: 02/06/96

"Therapy and Diagnosis of Conditions Related to Telomere Length and/or Telomerase Activity"

 #5,639,613 Issue data: 06/17/97

"Methods for Cancer Diagnosis and Prognosis"

 #5,645,986 Issue date: 07/08/97

"Telomerase Activity Inhibitor Screening"

 #5,648,215 Issue date: 07/15/97

"Telomerase Diagnostic Methods"

 #5,686,245 Issue date: 11/11/97

"Screening for Agents that Modulate Telomere Length"

 #5,686,306 Issue date: 11/11/97

"Methods and Reagents for Lengthening Telomeres"

#5,693,474 Issue date: 12/2/97

"Methods for Cancer Diagnosis and Prognosis"

#5,695,932 Issue date: 12/9/97

"Telomerase Activity Assays for Diagnosing Pathogenic Infections and Identifying Pathogen Telomerase Inhibitors"

 #5,707,795 Issue date: 1/13/98

"Diagnosis of Conditions Related to Telomere Length"

#5,830,644 Issue date: 11/3/98

"Method for Screening for Agents which Increase Telomerase Activity in a Cell"

Graduate School	University of Texas at Austin (1968)
Graduate School	University of Kansas Main Campus (1972)

• Cancer stem cells
• Cell Biology of the cancer genome
• Mechanisms of cellular immortalization
• Mouse models of radiation-induced cancer
• Role of telomeres and telomerase in cancer and aging

Featured Publications

Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth.

Eskiocak U, Kim SB, Ly P, Roig AI, Biglione S, Komurov K, Cornelius C, Wright WE, White MA, Shay JW Cancer Res. 2011 Jul 71 13 4359-65

Telomere position effect in human cells.

Baur, J.A., Shay, J.W. and Wright, W.E. Science 2001 292 2075-2077

Lack of cancer-associated changes in human fibroblasts after immortalization with telomerase.

Morales, C.P., Holt, S.E., Ouelette, M., Kaur, K.J., Wilson, K.S., White, M.A., Wright, W.E., and Shay, J.W, Nature Genetics 1999 21 115-118

Extension of lifespan by introduction of telomerase in normal human cells.

Bodnar, A.G., Ouellete, M., Frolkis, M., Holt, S.E., Chiu, C.P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S., and Wright, W.E. Science 1998 279 349-352

Correlating telomerase activity levels with human neuroblastoma outcomes.

Hiyama, E., Hiyama, K., Yokoyama, T., Matsuura, Y., Piatyszek, M.A., Shay, J.W. Nature Medicine 1995 1 249-357

Specific association of human telomerase activity with immortal cells and cancer.

Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L.C., Coviello, G.M., Wright, W.E., Weinrich, S.L., Shay, J.W. Science 1994 266 2011-2015

Two and three dimensional models for risk assessment of radiation-enhanced colorectal turmorigenesis

Roig, A. I. , Hight, S.K., and Shay, J.W. Radiation Research Fall 2008 in press

Actions of human telomerase beyond telomeres

Y-S Cong, J.W. Shay Cell Research Spring 2008 18 725-732

Adult-onset pulmonary fibrosis caused by mutations in telomerase

Tsakiri, K.D., Cronkite, J.T., Kuan, P.J. Xing, C., Ganesh, R., Weissler, J.C., Rosenblatt, R.L. Shay, J.W. Garcia, C.K PNAS Spring 2007 104 7552-7557

• Univeristy of Texas Health Science Education
  Elected Member (2012)
• University of Texas Regent's Outstanding Teaching Award
  Medal (2012)
• Doctor of the Decade (1995-2005)
  Ranked 6th Most Cited Author in General Biomedical Sicence (2006)
• Ted Nash Award
  Aging Research (2006)
• Hayflick Award
  American Aging Association (2001)
• Southland Financial Corporation
  Distinguished Chair in Geriatric Research (2001)
• Ellison Medical Foundation
  Senior Scholar Award (1999)