Philip Shaul, M.D.

Dr. Shaul received his BA from Dartmouth College and his MD from the University of Cincinnati. He received residency training in pediatrics at the Children?s Medical Center of Cincinnati/University of Cincinnati followed by fellowship training in neonatal-perinatal medicine at Women and Infant?s Hospital of Rhode Island/Brown University. He joined the faculty of the University of Texas Southwestern Medical Center at Dallas in 1986, and is currently Professor of Pediatrics and holder of the Lowe Foundation Professorship in Pediatric Critical Care Research at UT Southwestern. He is the Director of the Division of Pulmonary and Vascular Biology in the Department of Pediatrics and a member of the Integrative Biology Graduate Program in the Division of Basic Science. Dr. Shaul was President of the Society for Pediatric Research for 2005-2006.

Medical School	University of Cincinnati College of Medicine (1981)
Residency	Children's Hospital Medical Center -Cincinnati (1984)
Fellowship	Brown University/Medical School (1986)

• Neonatal & Perinatal Medicine
• Pediatrics

• Caveolae, lipid rafts
• Membrane-associated estrogen receptors
• Nitric oxide synthase
• Scavenger receptor class B, type I (HDL receptor)
• Signaling by C-reactive protein

Featured Publications

FcRIIB mediates C-reactive protein inhibition of endothelial NO synthase

Mineo C, Gormley AK, Yuhanna IS, Osborne-Lawrence S, Gibson LL, Hahner L, Shohet RV, Black S, Salmon JE, Samols D, Karp DR, Thomas GD, Shaul PW Circ. Res. 2005 97 1124-1131

Cholesterol binding, efflux and a PDZ-interacting domain of SR-BI mediate HDL-initiated signaling

Assanasen C, Mineo C, Seetharam D, Yuhanna IS, Marcel YL, Connelly MA, Williams DL, de la Llera-Moya M, Shaul PW, Silver DL J. Clin. Invest. 2005 115 969-977

High density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase

Yuhanna IS, Zhu Y, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, Anderson RGW, Mendelshoh ME, Hobbs HH, Shaul PW Nature Med. 2001 7 853-857

Estrogen receptor alpha mediates nongenomic activation of eNOS by estrogen

Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW J. Clin. Invest. 1999 130 401-406

Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae

Shaul PW, Smart EJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, Anderson RGW, Michel T J. Biol. Chem. 1996 271 6518-6522

27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that inhibits the cardiovascular effects of estrogen

Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Liverman AB, Javitt NB, Shaul PW, Mangelsdorf DJ Nat. Med. 2007

CRP causes downregulation of vascular AT2 receptors and systolic hypertension in mice

Vongpatanasin W, Thomas GD, Schwartz R, Cassis LA, Osborne-Lawrence S, Hahner L, Gibson LL, Black S, Samols D, Shaul PW Circulation 2007 115 1020-1028

Direct interactions with Galpha i and Gbeta-gamma mediate nongenomic signaling by ERalpha

Kumar P, Tall GG, Chambliss KL, Yuhanna IS, Wu Q, Mumby SM, Mineo C, Shaul PW Mol. Endocrinol. 2007 21 1370-1380

CRP downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice

Schwartz R, Osborne-Lawrence S, Hahner L, Gibson LL, Gormley AK, Vongpatanasin W, Zhu W, Word RA, Seetharam D, Black S, Samols D, Mineo C, Shaul PW Circ. Res. 2007 100 1452-1459

High density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I

Seetharam D, Mineo C, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW Circ. Res. 2006 98 63-72

• President, Society for Pediatric Research 2005-2006
  (2005)
• Codirector, Crystal Charity Ball Center for Research in Pediatric Critical Care
  (1997)
• Lowe Foundation Professorship in Pediatric Critical Care Research
  (1997)
• Established Investigator Award, AHA
  (1993)

• Association of American Physicians (2013)
• American Society for Clinical Investigation
• Dallas County Medical Society
• Fellow, American Academy of Pediatrics
• Perinatal Research Society
• Society for Pediatric Research