Biography

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Caroline de Gracia Lux received her Ph.D. in Chemistry from the University of Strasbourg under the mentorship of Marie Pierre Krafft, Ph.D. synthesizing and evaluating new classes of fluorinated surfactants to promote self-assembly and compartmentalized systems for material science applications.

Following her Ph.D., she completed postdoctoral training at UCSD focusing on biocompatible materials for theranostic applications. She was instrumental in the success of various projects on polymeric materials that degrade and release their contents in response to either abnormal biological conditions or by remote optical activation. She concurrently completed a Micro-MBA program at UCSD (Rady School of Management) that focused on communication, leadership in high performance teams, finance, strategy and marketing.

She recently joined the newly established Translational Research in Ultrasound Theranostics program at UT Southwestern Dept of Radiology. Her current research interest is combining creative synthetic chemistry and formulation to develop ultrasound contrast agent with sophisticated architecture aimed to address a wide range of challenges in cancer imaging and treatment.

Ongoing projects focus on the stabilization of low boiling point perfluorocarbon emulsion using a low interfacial tension approach, the development of new activatable ultrasound contrast agents and multimodal imaging probes.

Education

Undergraduate
(2005), Chemistry
Graduate School
(2007), Chemistry
Graduate School
(2010), Chemistry

Publications

Featured Publications LegendFeatured Publications

Short Soluble Coumarin Crosslinkers for Light Controlled Release of Cells and Proteins from Hydrogels.
de Gracia Lux C, Lux J, Collet G, He S, Chan M, Olejniczak J, Foucault-Collet A, Almutairi A Biomacromolecules 2015 Sep
Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye.
Huu VA, Luo J, Zhu J, Zhu J, Patel S, Boone A, Mahmoud E, McFearin C, Olejniczak J, de Gracia Lux C, Lux J, Fomina N, Huynh M, Zhang K, Almutairi A J Control Release 2015 Feb 200 71-7
Exploiting oxidative microenvironments in the body as triggers for drug delivery systems.
Joshi-Barr S, de Gracia Lux C, Mahmoud E, Almutairi A Antioxid. Redox Signal. 2014 Aug 21 5 730-54
Near-infrared-induced heating of confined water in polymeric particles for efficient payload release.
Viger ML, Sheng W, Doré K, Alhasan AH, Carling CJ, Lux J, de Gracia Lux C, Grossman M, Malinow R, Almutairi A ACS Nano 2014 May 8 5 4815-26
Collective activation of MRI agents via encapsulation and disease-triggered release.
Viger ML, Sankaranarayanan J, de Gracia Lux C, Chan M, Almutairi A J. Am. Chem. Soc. 2013 May 135 21 7847-50
Intramolecular Cyclization for Stimuli-Controlled Depolymerization of Polycaprolactone Particles Leading to Disassembly and Payload Release.
de Gracia Lux C, Almutairi A ACS Macro Lett 2013 May 2 5 432-435
Thermal behavior and high- and low-temperature phase structures of gemini fluorocarbon/hydrocarbon diblocks.
de Gracia Lux C, Donnio B, Heinrich B, Krafft MP Langmuir 2013 Apr 29 17 5325-36
Intramolecular cyclization assistance for fast degradation of ornithine-based poly(ester amide)s
de Gracia Lux C.; Olejniczak J.; Fomina N.; Viger M.L; .Almutairi A. J. Polym. Sci. Part A 2013 51 18 3783?3790
Biocompatible polymeric nanoparticles degrade and release cargo in response to biologically relevant levels of hydrogen peroxide.
de Gracia Lux C, Joshi-Barr S, Nguyen T, Mahmoud E, Schopf E, Fomina N, Almutairi A J. Am. Chem. Soc. 2012 Sep 134 38 15758-64
A Single UV or Near IR Triggering Event Leads to Polymer Degradation into Small Molecules.
de Gracia Lux C, McFearin CL, Joshi-Barr S, Sankaranarayanan J, Fomina N, Almutairi A ACS Macro Lett 2012 Jul 1 7 922-926