We are interested in a fundamental question in life sciences: How do cells make decisions?
This approach makes it possible to study cellular signaling and decision making with very high precision in real time, allowing us to use quantitative measurements to gain qualitative insights into how cell networks execute decisions.
Our main model organism is budding yeast, but we are also interested in other systems
- Graduate School
- Other (2010), Bioengineering
- single cell imaging
- systems biology
- Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition.
- Doncic A, Atay O, Valk E, Grande A, Bush A, Vasen G, Colman-Lerner A, Loog M, Skotheim JM Cell 2015 Mar 160 6 1182-95
- Feedforward regulation ensures stability and rapid reversibility of a cellular state.
- Doncic A, Skotheim JM Mol. Cell 2013 Jun 50 6 856-68
- An algorithm to automate yeast segmentation and tracking.
- Doncic A, Eser U, Atay O, Skotheim JM PLoS ONE 2013 8 3 e57970
- Distinct interactions select and maintain a specific cell fate.
- Doncic A, Falleur-Fettig M, Skotheim JM Mol. Cell 2011 Aug 43 4 528-39