Lukasz Joachimiak received his B.S. in Biochemistry from the University of Wisconsin-Madison in 2000. He received his Ph.D. in 2007 working in the lab of David Baker at University of Washington where he established computational tools to define the energetic and structural principles that underlie protein-protein interactions. He completed his postdoctoral work with Judith Frydman at Stanford University where he developed innovative approaches to understand the structure and mechanics of substrate interaction by the eukaryotic chaperonin TRiC/CCT.
At UT Southwestern Medical Center, Dr. Joachimiak's laboratory will utilize structural and biochemical approaches to dissect the role of chaperones and protein misfolding in neurodegenerative diseases. His group is also interested in integrating experimental and computational methods to predict the structures of protein complexes not tractable by classical structural biology techniques.
- University of Wisconsin - Madi (2001), Biochemistry
- Graduate School
- University of Washington (2007), Biochemistry
- Chaperone structual biology
- Molecular recognition and specificity
- The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT.
- Joachimiak LA, Walzthoeni T, Liu CW, Aebersold R, Frydman J Cell 2014 Nov 159 5 1042-55
- A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle.
- Reissmann S, Joachimiak LA, Chen B, Meyer AS, Nguyen A, Frydman J Cell Rep 2012 Oct 2 4 866-77
- The molecular architecture of the eukaryotic chaperonin TRiC/CCT.
- Leitner A, Joachimiak LA, Bracher A, Mönkemeyer L, Walzthoeni T, Chen B, Pechmann S, Holmes S, Cong Y, Ma B, Ludtke S, Chiu W, Hartl FU, Aebersold R, Frydman J Structure 2012 May 20 5 814-25
- A de novo protein binding pair by computational design and directed evolution.
- Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione GT, Spiegel CP, Liu DR, Baker D Mol. Cell 2011 Apr 42 2 250-60
- Computational redesign of protein-protein interaction specificity.
- Kortemme T, Joachimiak LA, Bullock AN, Schuler AD, Stoddard BL, Baker D Nat. Struct. Mol. Biol. 2004 Apr 11 4 371-9
Honors & Awards
- Endowed Scholar Award