Education

Graduate School
University of Louisville (1978), Biochemistry

Research Interest

  • Bone and Mineral Metabolism
  • Transcriptional Regulation
  • Vascular Calcification
  • Wnt Signaling

Publications

Featured Publications LegendFeatured Publications

Vascular Smooth Muscle LRP6 Limits Arteriosclerotic Calcification in Diabetic LDLR-/- Mice by Restraining Noncanonical Wnt Signals.
Cheng SL, Ramachandran B, Behrmann A, Shao JS, Mead M, Smith C, Krchma K, Bello Arredondo Y, Kovacs A, Kapoor K, Brill LM, Perera R, Williams BO, Towler DA Circ. Res. 2015 Jun
Targeted reduction of vascular Msx1 and Msx2 mitigates arteriosclerotic calcification and aortic stiffness in LDLR-deficient mice fed diabetogenic diets.
Cheng SL, Behrmann A, Shao JS, Ramachandran B, Krchma K, Bello Arredondo Y, Kovacs A, Mead M, Maxson R, Towler DA Diabetes 2014 Dec 63 12 4326-37
Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells.
Cheng SL, Shao JS, Behrmann A, Krchma K, Towler DA Arterioscler. Thromb. Vasc. Biol. 2013 Jul 33 7 1679-89
TNFR1-activated reactive oxidative species signals up-regulate osteogenic Msx2 programs in aortic myofibroblasts.
Lai CF, Shao JS, Behrmann A, Krchma K, Cheng SL, Towler DA Endocrinology 2012 Aug 153 8 3897-910
Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis.
Cheng SL, Shao JS, Halstead LR, Distelhorst K, Sierra O, Towler DA Circ. Res. 2010 Jul 107 2 271-82
Msx2 exerts bone anabolism via canonical Wnt signaling.
Cheng SL, Shao JS, Cai J, Sierra OL, Towler DA J. Biol. Chem. 2008 Jul 283 29 20505-22
Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- mice.
Al-Aly Z, Shao JS, Lai CF, Huang E, Cai J, Behrmann A, Cheng SL, Towler DA Arterioscler. Thromb. Vasc. Biol. 2007 Dec 27 12 2589-96
Four and half lim protein 2 (FHL2) stimulates osteoblast differentiation.
Lai CF, Bai S, Uthgenannt BA, Halstead LR, McLoughlin P, Schafer BW, Chu PH, Chen J, Otey CA, Cao X, Cheng SL J. Bone Miner. Res. 2006 Jan 21 1 17-28
Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals.
Shao JS, Cheng SL, Pingsterhaus JM, Charlton-Kachigian N, Loewy AP, Towler DA J. Clin. Invest. 2005 May 115 5 1210-20
MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors.
Cheng SL, Shao JS, Charlton-Kachigian N, Loewy AP, Towler DA J. Biol. Chem. 2003 Nov 278 46 45969-77

Honors & Awards

  • Outstanding Basic Science Research Award
    The Cervical Spine Research Society (2000)
  • Russell S. Fibbs Basic Science Research Award
    Scoliosis Research Society (2000)
  • Young Investigator Award
    American Society for Bone and Mineral Research (1988)

Professional Associations/Affiliations

  • The American Society for Bone and Mineral Research (1988)