Beverly Rothermel, Ph.D.

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EDUCATION/TRAINING

 Cornell University; Ithaca, NY, BS 1982 Biology/Biochemistry

Yale University, New Haven, CT, MS 1986 Biology

Yale University, New Haven, CT, MPhil 1987 Biology

Yale University, New Haven, CT, PhD 1991 Cellular & Development

 

RESEARCH AND PROFESSIONAL EXPERIENCE:

1981-1982 Research Assistant, Boyce Thompson Institute, Ithaca, NY

1982-1983 Research Assistant with L.E. Anderson, University of Illinois, Chicago, IL

1984 Research Assistant with R. L. Satter, University of Connecticut, Storrs, CT

1984 Graduate Researchwith N. Ornston, Yale University, New Haven, CT

1985-1990 Graduate Research with T. Nelson, Yale University, New Haven, CT

1991-1996 Postdoctoral training with Drs. R. Butow and P. Perlman, UT Southwestern

1996-2000 Postdoctoral training with Dr. R. Sanders Williams, UT Southwestern

2000-present Assistant Professor, Internal Medicine, UT Southwestern

 

PROFESSIONAL ACTIVITES

1996-1997 Freelance editor for Current Protocols (John Wiley and Sons, NY)

1993-present American Genetic Society

1983-present American Association for the Advancement of Science

 

HONORS AND AWARDS

National Merit Scholar NIH Individual National Research Service Award NIH Institutional Research Fellowship American Cancer Society Postdoctoral Fellowship

 

ONGOING RESEARCH SUPPORT

NIH RO1 HL072016       Rothermel (PI)                                                              12/13/2002 - 06/30/2013. Modulating Calcineurin Signaling Pathways in MuscleThe goal of this project is to decipher the mechanisms through which modulatory calcineurin-interacting proteins (MCIPs/RCANs) influence calcineurin signaling in heart and skeletal muscle.                     

NIH R01 HL097768    Rothermel (PI)                                                            09/01/2009 - 08/31/2013        Calcineurin's role in circadian regulation of cardiac function and remodeling.  The goal of this grant is to study circadian regulation of signaling pathways that control cardiac function.

NIH RO1 HL090842                (Co-PI)                                                          04/01/2009 - 08/31/2013  FoxO: Negative regulator of Cardiac Hypertrophy

NIH R01 HL098051-01             (Co-PI)                                                        04/01/2012 - 03/31/2017         Cytoglobin: A stress-responsive hemoprotein modulating cardiomyocyte Role: Co-Investigator

AHA DeHaan Cardiac Myogenesis Research Center       Olson (PI)                     04/01/2009 - 12/31/2012 Chemical Regulation of Cardiac Regeneration and Repair  (Role: Director of Cardiac Surgery and Physiology Core)

Undergraduate	Cornell University (1982), Biology
Graduate School	Yale University (1991), Biology

• circadian rhythms
• intracellular signaling
• molecular and developmental cardiology
• nuclear-mitochondrial interactions
• transcriptional regulation

Featured Publications

Targets, trafficking, and timing of cardiac autophagy.

Rotter D, Rothermel BA Pharmacol. Res. 2012 Dec 66 6 494-504

Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart.

Sachan N, Dey A, Rotter D, Grinsfelder B, Battiprolu PK, Sikder D, Copeland V, Oh M, Bush E, Shelton JM, Bibb A, Hill A, Rothermel BA Circ Research 2011 108 437-445

Regulator of calcineurin 1 controls growth plasticity of adult pancreas.

Gurda GT, Crozier SJ, Ji B, Ernst SA, Logsdon CD, Rothermel BA, Williams JA Gastroenterology 2010 Aug 139 2 609-19, 619.e1-6

Mitochondrial Fission and Autophagy in the Normal and Diseased Heart

Iglewski M, Hill JA, Lavandero S, Rothermel BA Curr Hypertens Rep 2010 12 418-425

Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy

Tannous P, Zhu H, Nemchenko A, Berry JM, Johnstone JL, Shelton JM, Miller FJ, Rothermel BA, Hill JA Circulation 2008 117 3070-3078

The Down Syndrome Critical Region Protein RCAN1 Regulates LTP and Memory via Inhibition of Phosphatase Signaling

Hoeffer CA, Dey A, Sachan N, Wong H, Patterson RJ, Shelton JM, Richardson JA, Klann E, Rothermel BA J Neurosci 2007 27 13161-13172

Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers

Oh M, Rybkin I, Copeland V, Czubryt MP, Shelton J, Richardson JA, Hill JA, de Windt LJ, Bassel-Duby R, Olson EN, Rothermel BA Mol Cell Biol 2005 25 6629-6638

Myocyte-enriched calcineurin interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

Rothermel BA, McKinsey TA, Vega RB, Nicol RL, Mammen P, Yang J, Antos CL, Shelton JM, Bassel-Duby R, Olson EN, Williams RS Proc Natl Acad Sci USA 2001 98 3328-3333

Cell death and survival through the endoplasmic reticulum-mitochondrial axis.

Bravo-Sagua R, Rodriguez AE, Kuzmicic J, Gutierrez T, Lopez-Crisosto C, Quiroga C, Díaz-Elizondo J, Chiong M, Gillette TG, Rothermel BA, Lavandero S Curr. Mol. Med. 2012 Dec

FHL2 binds calcineurin and represses pathological cardiac growth.

Hojayev B, Rothermel BA, Gillette TG, Hill JA Mol. Cell. Biol. 2012 Oct 32 19 4025-34

• American Cancer Society Postdoctoral Fellowship
  (0)
• National merit Scholar
  (0)
• NIH Individual National research Service Award
  (0)
• NIH Institutional Research Fellowship
  (0)

• American Association for the Advancement of Science
• American Genetics Society
• American Heart Association
• Genetics Society of America
• Society For Research in Biological Rhythms