Michael Roth, Ph.D.

Professor

Endowed Title: Diane and Hal Brierley Distinguished Chair in Biomedical Research

Department: Biochemistry, Office of the Dean - Southwestern Graduate School

Graduate Programs: Cancer Biology, Cell Regulation

Biography

Michael Roth received an AB degree in 1971 from Davidson College and taught high school science in Alexandria Virginia before obtaining a PhD in Cell and Molecular Biology from the University of Alabama at Birmingham in 1982. He was a Damon Runyon Cancer Research Foundation postdoctoral fellow from 1982-1983 and a NIH postdoctoral fellow from 1983-1985 with Drs. Joe Sambrook and Mary-Jane Gething at Cold Spring Harbor Laboratory. He joined the faculty at UT Southwestern in 1985, was promoted to professor in 1996 and that year received the Diane and Hal Brierley Chair in Biomedical Research.

 

Dr. Roth’s current research interests focus on drug discovery. Active research programs in the Roth laboratory target virus pathogens, cancer and diabetes with an emphasis in using genetics and cell biology to determine the mechanisms by which novel chemical compounds affect living organisms. Dr. Roth is a founding member of the University of Texas Academy of Health Science Education and a member of Southwestern Academy of Teachers.

Education

Undergraduate Davidson College (1971), French Literature
Graduate School University of Alabama at Birmingham (1982)

Research Interests

  • antiviral therapeutics, viruses, host defense against virus
  • Biochemistry and Cell Biology
  • Diabetes, Type I & II
  • Drug discovery
  • High-throughput screening of chemical compound libraries.
  • High-throughput screening of RNAi libraries.
  • Intracellular traffic in membrane proteins and lipids.
  • Lung Cancer

Publications

Featured Publications Legend

Featured Publications

TDP-43 Identified from a Genome Wide RNAi Screen for SOD1 Regulators.

Somalinga BR, Day CE, Wei S, Roth MG, Thomas PJ PLoS ONE 2012 7 4 e35818

Host modulators of H1N1 cytopathogenicity.

Ward SE, Kim HS, Komurov K, Mendiratta S, Tsai PL, Schmolke M, Satterly N, Manicassamy B, Forst CV, Roth MG, García-Sastre A, Blazewska KM, McKenna CE, Fontoura BM, White MA PLoS ONE 2012 7 8 e39284

Results 1-10 of 20

Honors/Awards

  • UT Southwestern Academy of Teachers
    (2011)
  • Distinguished Teaching Professor
    (2005)
  • Member, UT Academy of Health Science Education
    (2005)
  • Diane and Hal Brierley Distinguished Chair in Biomedical Research
    (1996)
  • Established Investigator of the American Heart Association
    (1989)

Professional Associations/Affiliations

  • American Chemical Society (2013)
  • Faculty1000 (2004)
  • Editorial Board: Traffic (2000)
  • Amercian Society for Cell Biology (1982)
  • American Association for the Advancement of Science
  • American Society for Biochemistry and Molecular Biology