Biography

Michael Roth received an AB degree in 1971 from Davidson College and taught high school science in Alexandria Virginia before obtaining a PhD in Cell and Molecular Biology from the University of Alabama at Birmingham in 1982. He was a Damon Runyon Cancer Research Foundation postdoctoral fellow from 1982-1983 and a NIH postdoctoral fellow from 1983-1985 with Drs. Joe Sambrook and Mary-Jane Gething at Cold Spring Harbor Laboratory. He joined the faculty at UT Southwestern in 1985, was promoted to professor in 1996 and that year received the Diane and Hal Brierley Chair in Biomedical Research.

 

Dr. Roth’s current research interests focus on drug discovery. Active research programs in the Roth laboratory target virus pathogens, cancer and diabetes with an emphasis in using genetics and cell biology to determine the mechanisms by which novel chemical compounds affect living organisms. Dr. Roth is a founding member of the University of Texas Academy of Health Science Education and a member of Southwestern Academy of Teachers.

Education

Undergraduate Davidson College (1971), French Literature
Graduate School University of Alabama at Birmingham (1982)

Research Interest

  • antiviral therapeutics, viruses, host defense against virus
  • Biochemistry and Cell Biology
  • Diabetes, Type I & II
  • Drug discovery
  • High-throughput screening of chemical compound libraries.
  • High-throughput screening of RNAi libraries.
  • Intracellular traffic in membrane proteins and lipids.
  • Lung Cancer

Publications

Featured Publications LegendFeatured Publications

A New Biology of Diabetes Revealed by Leptin.
Unger RH, Roth MG Cell Metab. 2014 Nov
Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells.
Lee Y, Berglund ED, Yu X, Wang MY, Evans MR, Scherer PE, Holland WL, Charron MJ, Roth MG, Unger RH Proc. Natl. Acad. Sci. U.S.A. 2014 Aug

Honors & Awards

  • UT Southwestern Academy of Teachers
    (2011)
  • Distinguished Teaching Professor
    (2005)
  • Member, UT Academy of Health Science Education
    (2005)
  • Diane and Hal Brierley Distinguished Chair in Biomedical Research
    (1996)
  • Established Investigator of the American Heart Association
    (1989)

Professional Associations/Affiliations

  • American Chemical Society (2013)
  • Faculty1000 (2004)
  • Editorial Board: Traffic (2000)
  • American Society for Cell Biology (1982)
  • American Association for the Advancement of Science
  • American Society for Biochemistry and Molecular Biology