Dr. Rosenfeld attended college at Emory University and graduated from Emory University School of Medicine. He completed his general training in Pediatrics at Yale-New Haven Medical Center and Albert Einstein College of Medicine, where he also was Chief Resident. He then spent a year as a Pediatric Pulmonary Fellow with Amile Scarpelli, MD, PhD at Albert Einstein, followed by 2 yrs in the Perinatal Research Program at the University of Colorado Health Sciences Center under the mentoring of Frederick Battaglia, MD and Giacomo Meschia, MD. After joining the faculty at UT Southwestern in 1973, Dr. Rosenfeld established a perinatal biology laboratory for the study of cardiovascular changes in pregnancy, and in particular, the study of uteroplacental and umbilicoplacental blood flows. He has received nearly continuous funding from NIH for his studies of the mother and fetus for 32 yrs, as well as other grants, making contributions to our understanding of cardiovascular changes in pregnancy and during fetal and neonatal development. He was the Director of the Division of Neonatal-Perinatal Medicine for nearly 35 yrs and has provided research training and mentoring for more than 15 fellows in his specialty, 5 in Maternal-Fetal Medicine, and numerous postdoctoral and medical students. His publication record exceeds 150 peer-reviewed articles and chapters in several textbooks. Dr Rosenfeld was the 2005 recipient of the Founders Award given by the Southern Society for Pediatric Research for his research contributions to child health and was elected a Fellow in the Section of Heart and Circulatory Physiology, American Physiological Society in 2005.
- Medical School
- Emory University School of Medicine (1966)
- Yale-New Haven Hospital (1967), Pediatrics
- Albert Einstein Medical Center (1969), Pediatrics
- Albert Einstein Medical Center (1970), Pediatrics
- Bronx Municipal Hospital Ctr. (1971), Cardiopulmonary
- University of Colorado Health Sciences Center (1973), Neonatal-perinatal Medicine
- Fetal Growth, Effects on Adult Disease
- Infection & Diagnosis
- Patent Ductus Arteriosus (PDA) Closure
- Placenta Blood Flow Regulation
- Blood pressure regulation before and after birth
- Cardiovascular role of estrogen in pregnancy
- Development of the renin-angiotensin system
- Mechanisms modulating uteroplacental blood flow
- Differential sensitivity to angiotensin II and norepinephrine in human uterine arteries.
- Rosenfeld CR, DeSpain K, Word RA, Liu X-t J Clin Endocrinol Metab 2012 97 138-147
- Pregnancy modifies the large conductance Ca2+-activated K+ channel expression and cGMP-dependent signaling pathway in uterine vascular smooth muscle
- Rosenfeld CR, , Liu X-t, and DeSpain K Am J Physiol: Heart Circ Physiol 2009 296
- Ca2+ -activated K+channels modulate basal and E2 -induced rises in uterine blood flow in ovine pregnancy.
- Rosenfeld CR, Cornfield DN, and Roy T Am J Physiol: Heart Circ Physiol 2001 281 H22-H31
- Ontogeny of vascular angiotensin II receptor subtype expression in ovine development.
- Cox BE and Rosenfeld CR Pediatr Res 1999 45 414-424
- Effect of angiotensin II on uterine and systemic vasculature in pregnant sheep.
- Naden RP and Rosenfeld CR J Clin Invest 1981 68 468-474
- Circulatory changes in the reproductive tissues of ewes during pregnancy.
- Rosenfeld CR, Morris FH, Jr., Makowski EL, Meschia G, and Battaglia FC. Gynecol Invest 1974 5 252-268
- Regulation of the cGMP-cPKG pathway and large- conductance Ca2+-activated K+ channels uterine arteries during the ovine ovarian cycle.
- Khan L, Rosenfeld CR, Liu X, Magness RR. Am J Physiol Endocrin Metabol, 2010 298 E222-E228
- Large conductance Ca+2-activated K+ channels contribute to vascular function in nonpregnant human uterine arteries.
- Rosenfeld CR, Word RA, DeSpain K, Liu X-t. Reprod Sciences 2008 15 651-660
- The renin-angiotensin system in conscious newborn sheep: metabolic clearance rate and activity.
- Velaphi SC, DeSpain K, Roy T, and Rosenfeld CR Pediatr Res 2007 61 681-686
- Vascular development beginning in early ovine gestation: carotid smooth muscle function, phenotype and biochemical markers.
- Hutuna, C, Cox BE, Liu X-t, DeSpain, K and Rosenfeld CR Am J Physiol: Regulatory Integrative Comp Physiol 2007 293 323-333
Honors & Awards
- SSPR Founders Award
Recognition for research contributing to improving child health, Southern Society of Pediatric Research (2005)
- Associate Editor, Reproductive Sciences (JSGI)
Appointed to the initial Editorial Board; evaluating basic research (1993)
- George L. Mac Gregor Professorship of Pediatrics - 1993-Present
Recognition for research contributions in Perinatal Medicine (1993)
- Associate Editor, Early Human Development
Responsible for all manuscripts in the Americas (1986)
- Perinatal Research Society
Recognition for contributions to studies in pregnancy and development (1981)
- American Academy of Pediatrics
- American Pediatric Society
- American Physiologic Society
- Society for Gynecologic Investigation
- Society for Pediatric Research