Charles Rosenfeld, M.D.

Professor

Endowed Title: George L. MacGregor Professorship in Pediatrics

Department: Pediatrics, Anesthesiology & Pain Management, Obstetrics & Gynecology

Graduate Programs: Integrative Biology

Biography

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Dr. Rosenfeld attended college at Emory University and graduated from Emory University School of Medicine. He completed his general training in Pediatrics at Yale-New Haven Medical Center and Albert Einstein College of Medicine, where he also was Chief Resident. He then spent a year as a Pediatric Pulmonary Fellow with Amile Scarpelli, MD, PhD at Albert Einstein, followed by 2 yrs in the Perinatal Research Program at the University of Colorado Health Sciences Center under the mentoring of Frederick Battaglia, MD and Giacomo Meschia, MD. After joining the faculty at UT Southwestern in 1973, Dr. Rosenfeld established a perinatal biology laboratory for the study of cardiovascular changes in pregnancy, and in particular, the study of uteroplacental and umbilicoplacental blood flows. He has received nearly continuous funding from NIH for his studies of the mother and fetus for 32 yrs, as well as other grants, making contributions to our understanding of cardiovascular changes in pregnancy and during fetal and neonatal development. He was the Director of the Division of Neonatal-Perinatal Medicine for nearly 35 yrs and has provided research training and mentoring for more than 15 fellows in his specialty, 5 in Maternal-Fetal Medicine, and numerous postdoctoral and medical students. His publication record exceeds 150 peer-reviewed articles and chapters in several textbooks. Dr Rosenfeld was the 2005 recipient of the Founders Award given by the Southern Society for Pediatric Research for his research contributions to child health and was elected a Fellow in the Section of Heart and Circulatory Physiology, American Physiological Society in 2005.

Education

Medical School Emory University School of Medicine (1966)
Internship Yale-New Haven Hospital (1967), Pediatrics
Residency Albert Einstein Medical Center (1969), Pediatrics
Residency Albert Einstein Medical Center (1970), Pediatrics
Fellowship Bronx Municipal Hospital Ctr. (1971), Cardiopulmonary
Fellowship University of Colorado Health Sciences Center (1973), Perinatal-neonatal Medicine

Specialty Areas

Clinical Interests

  • Blood Pressure Regulation
  • Fetal Growth, Effects on Adult Disease
  • Infection & Diagnosis
  • Patent Ductus Arteriosus
  • Placenta Blood Flow Regulation

Research Interests

  • Blood pressure regulation before and after birth
  • Cardiovascular role of estrogen in pregnancy
  • Development of the renin-angiotensin system
  • Mechanisms modulating uteroplacental blood flow

Publications

Featured Publications Legend

Featured Publications

Regulation of the cGMP-cPKG pathway and large- conductance Ca2+-activated K+ channels uterine arteries during the ovine ovarian cycle.

Khan L, Rosenfeld CR, Liu X, Magness RR. Am J Physiol Endocrin Metabol, 2010 298 E222-E228

Large conductance Ca+2-activated K+ channels contribute to vascular function in nonpregnant human uterine arteries.

Rosenfeld CR, Word RA, DeSpain K, Liu X-t. Reprod Sciences 2008 15 651-660

The renin-angiotensin system in conscious newborn sheep: metabolic clearance rate and activity.

Velaphi SC, DeSpain K, Roy T, and Rosenfeld CR Pediatr Res 2007 61 681-686

Vascular development beginning in early ovine gestation: carotid smooth muscle function, phenotype and biochemical markers.

Hutuna, C, Cox BE, Liu X-t, DeSpain, K and Rosenfeld CR Am J Physiol: Regulatory Integrative Comp Physiol 2007 293 323-333

Results 1-10 of 12

Honors/Awards

  • SSPR Founders Award
    Recognition for research contributing to improving child health, Southern Society of Pediatric Research (2005)
  • Associate Editor, Reproductive Sciences (JSGI)
    Appointed to the initial Editorial Board; evaluating basic research (1993)
  • George L. Mac Gregor Professorship of Pediatrics - 1993-Present
    Recognition for research contributions in Perinatal Medicine (1993)
  • Associate Editor, Early Human Development
    Responsible for all manuscripts in the Americas (1986)
  • Perinatal Research Society
    Recognition for contributions to studies in pregnancy and development (1981)

Professional Associations/Affiliations

  • American Academy of Pediatrics
  • American Pediatric Society
  • American Physiologic Society
  • Society for Gynecologic Investigation
  • Society for Pediatric Research