Peter Douglas, Ph.D., is an assistant professor in the Department of Molecular Biology at UT Southwestern Medical Ceneter. He receiving his bachelor’s degree in Biochemistry from the University of Colorado in Boulder and earned his Ph.D. from the University of North Carolina in Chapel Hill in the Department of Cell and Developmental Biology. As a graduate student in laboratory of Dr. Douglas Cyr, Peter used different methods in biochemistry, genetics, and cell biology to understand the mechanisms by which protein homeostasis machinery detoxifies misfolded, aggregation-prone proteins. In 2009, he joined the laboratory of Andrew Dillin at the Salk Institute in La Jolla, California, and later the University of California in Berkeley, California. There he uncovered novel links between classical stress response function and the actin cytoskeleton network. In 2015, Peter joined the faculty at UT Southwestern as an assistant professor in the Department of Molecular Biology. Peter was awarded fellowships from the American Heart Association, National Institute of Health on the Neuroplasticity of Aging and the George E. Hewitt Medical Foundation. He also received a Pathway to Independence Award (K99/R00) from the National Institute of Health. As a assistant professor, Peter received a Cancer Prevention Research Institute of Texas (CPRIT) recruitment of first-time, tenure-track faculty member award and is an Endowed Scholar in biomedical research.
- Cancer Biology
- Molecular Genetics of Aging
- Protein Homeostasis
- Stress Response Signaling
- Traumatic Brain Injury
- Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity.
- Douglas PM, Baird NA, Simic MS, Uhlein S, McCormick MA, Wolff SC, Kennedy BK, Dillin A Cell Rep 2015 Aug
- HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span.
- Baird NA, Douglas PM, Simic MS, Grant AR, Moresco JJ, Wolff SC, Yates JR, Manning G, Dillin A Science 2014 Oct 346 6207 360-3
- Reciprocal efficiency of RNQ1 and polyglutamine detoxification in the cytosol and nucleus.
- Douglas PM, Summers DW, Ren HY, Cyr DM Mol. Biol. Cell 2009 Oct 20 19 4162-73
- Chaperone-dependent amyloid assembly protects cells from prion toxicity.
- Douglas PM, Treusch S, Ren HY, Halfmann R, Duennwald ML, Lindquist S, Cyr DM Proc. Natl. Acad. Sci. U.S.A. 2008 May 105 20 7206-11
- The disposable soma theory of aging in reverse.
- Douglas PM, Dillin A Cell Res. 2014 Jan 24 1 7-8
- RPN-6 determines C. elegans longevity under proteotoxic stress conditions.
- Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, Rodrigues AP, Manning G, Dillin A Nature 2012 Sep 489 7415 263-8
- Protein homeostasis and aging in neurodegeneration.
- Douglas PM, Dillin A J. Cell Biol. 2010 Sep 190 5 719-29
- Interplay between protein homeostasis networks in protein aggregation and proteotoxicity.
- Douglas PM, Cyr DM Biopolymers 2010 Mar 93 3 229-36
- Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones.
- Summers DW, Douglas PM, Ramos CH, Cyr DM Trends Biochem. Sci. 2009 May 34 5 230-3
- Prion propagation by Hsp40 molecular chaperones.
- Summers DW, Douglas PM, Cyr DM Prion 2009 Apr-Jun 3 2 59-64
Honors & Awards
- Cancer Prevention Research Institute of Texas (CPRIT) Scholar Recruitment of First-Time, Tenure-Track Faculty Members (2015)
- University of Texas Southwestern Medical Center Endowed Scholar
- K99/R00 Pathway to Independence Award NIH/NIA
- George Hewitt Medical Foundation Scholar
- Neuroplasticity of Aging Postdoctoral Training Fellowship
- American Heart Association Pre-Doctoral Fellowship
- Hamon Center for Regenerative Science and Medicine (2015)