Biography

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Vincent (Vinnie) Tagliabracci is an Assistant Professor in the Department of Molecular Biology at UT Southwestern Medical Center.  He received his B.S. in Chemistry and Biology from the University of Indianapolis and his Ph.D. in Biochemistry and Molecular Biology from Indiana University under the supervision of Dr. Peter Roach, where he made several important contributions to understanding how elevated levels of glycogen phosphate cause Lafora Disease, a deadly form of epilepsy.  In 2010, Vinnie joined the laboratory of Dr. Jack Dixon as a postdoctoral fellow at the University of California, San Diego in La Jolla, CA.  There, he discovered a novel family of “secreted” kinases that phosphorylate proteins destined for secretion from the cell.  As part of this work, he identified Fam20C as the bona fide "Golgi casein kinase", an enzyme that escaped identification for many years.  In 2015, he joined the faculty at UT Southwestern as an Assistant Professor in the Department of Molecular Biology.  Vinnie is the recipient of the Esther L. Kinsley dissertation award from Indiana University School of Medicine, a K99/R00 Pathway to Independence award from the National Institutes of Health, a Cancer Prevention Research Institute of Texas (CPRIT) recruitment of first-time, tenure-track faculty member award and is an Endowed Scholar in biomedical research. 

Education

Undergraduate
University of Indianapolis (2005), Chemistry
Undergraduate
University of Indianapolis (2005), Biology
Graduate School
Indiana Univ Purdue Univ Sch M (2010), Molecular Biology
Graduate School
Indiana Univ Purdue Univ Sch M (2010), Biochemistry

Research Interest

  • Cancer Biology
  • CRISPR Genome Editing
  • Kinases in the Secretory Pathway and Extracellular Space
  • Phosphorylation of Secreted Proteins
  • Signal Transduction

Publications

Featured Publications LegendFeatured Publications

The secretory pathway kinases.
Sreelatha A, Kinch LN, Tagliabracci VS Biochim. Biophys. Acta 2015 Apr
A secretory kinase complex regulates extracellular protein phosphorylation.
Cui J, Xiao J, Tagliabracci VS, Wen J, Rahdar M, Dixon JE Elife 2015 Mar 4
Phosphate incorporation during glycogen synthesis and Lafora disease.
Tagliabracci VS, Heiss C, Karthik C, Contreras CJ, Glushka J, Ishihara M, Azadi P, Hurley TD, DePaoli-Roach AA, Roach PJ Cell Metab. 2011 Mar 13 3 274-82
Abnormal metabolism of glycogen phosphate as a cause for Lafora disease.
Tagliabracci VS, Girard JM, Segvich D, Meyer C, Turnbull J, Zhao X, Minassian BA, Depaoli-Roach AA, Roach PJ J. Biol. Chem. 2008 Dec 283 49 33816-25

Honors & Awards

  • ASMB Junior Investigator Award
    (2016)
  • Cancer Prevention Research Institute of Texas (CPRIT) Scholar
    Recruitment of First-Time, Tenure-Track Faculty Members (2015)
  • UT Southwestern Endowed Scholar
    (2015)
  • K99/R00 Pathway to Independence Award
    NIH (2014-2019)
  • Esther L. Kinsley PhD Dissertation Award
    Indiana University (2011)