Vincent (Vinnie) Tagliabracci is an Assistant Professor in the Department of Molecular Biology at UT Southwestern Medical Center. He received his B.S. in Chemistry and Biology from the University of Indianapolis and his Ph.D. in Biochemistry and Molecular Biology from Indiana University under the supervision of Dr. Peter Roach, where he made several important contributions to understanding how elevated levels of glycogen phosphate cause Lafora Disease, a deadly form of epilepsy. In 2010, Vinnie joined the laboratory of Dr. Jack Dixon as a postdoctoral fellow at the University of California, San Diego in La Jolla, CA. There, he discovered a novel family of “secreted” kinases that phosphorylate proteins destined for secretion from the cell. As part of this work, he identified Fam20C as the bona fide "Golgi casein kinase", an enzyme that escaped identification for many years. In 2015, he joined the faculty at UT Southwestern as an Assistant Professor in the Department of Molecular Biology. Vinnie is the recipient of the Esther L. Kinsley dissertation award from Indiana University School of Medicine, a K99/R00 Pathway to Independence award from the National Institutes of Health, a Cancer Prevention Research Institute of Texas (CPRIT) recruitment of first-time, tenure-track faculty member award and is an Endowed Scholar in biomedical research.
- University of Indianapolis (2005), Chemistry
- University of Indianapolis (2005), Biology
- Graduate School
- Indiana Univ Purdue Univ Sch M (2010), Molecular Biology
- Graduate School
- Indiana Univ Purdue Univ Sch M (2010), Biochemistry
- Cancer Biology
- CRISPR Genome Editing
- Kinases in the Secretory Pathway and Extracellular Space
- Phosphorylation of Secreted Proteins
- Signal Transduction
- Phosphorylation of spore coat proteins by a family of atypical protein kinases.
- Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawlowski K, Dixon JE, Tagliabracci VS Proc. Natl. Acad. Sci. U.S.A. 2016 May
- A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
- Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE Cell 2015 Jun 161 7 1619-32
- Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis.
- Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Koller A, Nizet V, White KE, Dixon JE Proc. Natl. Acad. Sci. U.S.A. 2014 Apr 111 15 5520-5
- Crystal structure of the Golgi casein kinase.
- Xiao J, Tagliabracci VS, Wen J, Kim SA, Dixon JE Proc. Natl. Acad. Sci. U.S.A. 2013 Jun 110 26 10574-9
- Secreted protein kinases.
- Tagliabracci VS, Pinna LA, Dixon JE Trends Biochem. Sci. 2013 Mar 38 3 121-30
- Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.
- Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon JE Science 2012 Jun 336 6085 1150-3
- The secretory pathway kinases.
- Sreelatha A, Kinch LN, Tagliabracci VS Biochim. Biophys. Acta 2015 Apr
- A secretory kinase complex regulates extracellular protein phosphorylation.
- Cui J, Xiao J, Tagliabracci VS, Wen J, Rahdar M, Dixon JE Elife 2015 Mar 4
- Phosphate incorporation during glycogen synthesis and Lafora disease.
- Tagliabracci VS, Heiss C, Karthik C, Contreras CJ, Glushka J, Ishihara M, Azadi P, Hurley TD, DePaoli-Roach AA, Roach PJ Cell Metab. 2011 Mar 13 3 274-82
- Abnormal metabolism of glycogen phosphate as a cause for Lafora disease.
- Tagliabracci VS, Girard JM, Segvich D, Meyer C, Turnbull J, Zhao X, Minassian BA, Depaoli-Roach AA, Roach PJ J. Biol. Chem. 2008 Dec 283 49 33816-25
Honors & Awards
- ASMB Junior Investigator Award
- Cancer Prevention Research Institute of Texas (CPRIT) Scholar
Recruitment of First-Time, Tenure-Track Faculty Members (2015)
- UT Southwestern Endowed Scholar
- K99/R00 Pathway to Independence Award
- Esther L. Kinsley PhD Dissertation Award
Indiana University (2011)