Barbara Stopschinski, M.D.
Instructor
School Medical School
Department Neurology | Center for Alzheimer's and Neurodegenerative Diseases
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Biography
Barbara Stopschinski, M.D., is originally from Essen in Germany. She graduated from Medical School at Ruhr University in Bochum, Germany in 2010. During this time, she completed her medical thesis with a focus on actin nucleation at the Max Planck Institute for Molecular Physiology in Dortmund, Germany. She then completed 4 years of residency training in neurology at the University Hospital in Aachen, Germany. She joined the Diamond laboratory in the Center for Alzheimer’s and Neurodegenerative Diseases here at UTSW as a postdoctoral fellow between 2015-2019, working on mechanisms of cellular tau uptake in tauopathies. She completed her residency in Neurology at UTSW in June 2023, and subsequently joined the faculty in July 2023 as Instructor and fellow in behavioral neurology. She has her own research laboratory with a focus on the molecular and cellular mechanisms driving tau uptake and propagation, and the mechanisms connecting neuroinflammation and neurodegeneration in tauopathies. Her research interests are directly connected with her clinical practice, where she treats patients with cognitive impairment and dementia such as Alzheimer’s Disease and other neurodegenerative conditions.
Education
- Medical School
- Ruhr University Bochum (2010), None
Research Interest
- Cellular and molecular mechanisms of neurodegeneration in tauopathies
- Cellular mechanisms of tau uptake and propagation
- The association between neuroinflammation and neurodegeneration in tauopathies
- The impact of heparan sulfate proteoglycans on tau pathophysiology
Publications
- Blood Markers in Relation to a History of Traumatic Brain Injury Across Stages of Cognitive Impairment in a Diverse Cohort
- Lobue C, Stopschinski BE, Saez Calveras N, Douglas PM, Huebinger R, Cullum CM, Hart J, Gonzales MM Journal of Alzheimer's Disease 2024 Jan 97 345-358
- DnaJC7 specifically regulates tau seeding
- Perez VA, Sanders DW, Mendoza-Oliva A, Stopschinski BE, Mullapudi V, White CL, Joachimiak LA, Diamond MI eLife 2023 Jun 12
- Microglia as a cellular target of diclofenac therapy in Alzheimer’s disease
- Stopschinski BE, Weideman RA, McMahan D, Jacob DA, Little BB, Chiang HS, Saez Calveras N, Stuve O Therapeutic Advances in Neurological Disorders 2023 Jan 16
- Clinical Reasoning: A 59-Year-Old Man with Thymoma and Constitutional Symptoms, Seizures, and Multifocal CNS Lesions
- Stopschinski BE, Fredrich S, Vernino S, Phillips L, Blackburn KM Neurology 2022 Dec 99 1115-1121
- Evidence-Based Evaluation and Management of Cognitive Impairment in Dementia With Lewy Bodies
- Khera A, Stopschinski BE, Chiang HS Psychiatric Annals 2022 Oct 52 404-409
- Cognitive Decline in Older People with Multiple Sclerosis—A Narrative Review of the Literature
- Chiang HS, Khera A, Stopschinski BE, Stuve O, Hart J, Kelley B, Nguyen T Geriatrics (Switzerland) 2022 Jun 7
- Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns
- Stopschinski BE, Del Tredici K, Estill-Terpack SJ, Ghebremdehin E, Yu FF, Braak H, Diamond MI Acta Neuropathologica Communications 2021 Dec 9
- A synthetic heparinoid blocks Tau aggregate cell uptake and amplification
- Stopschinski BE, Thomas TL, Nadji S, Darvish E, Fan L, Holmes BB, Modi AR, Finnell JG, Kashmer OM, Estill-Terpack S, Mirbaha H, Luu HS, Diamond MI Journal of Biological Chemistry 2020 Mar 295 2974-2983
- Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus -synuclein and -amyloid aggregates
- Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI Journal of Biological Chemistry 2018 Jul 293 10826-10840
- Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres
- Al Haj A, Mazur AJ, Radaszkiewicz K, Radaszkiewicz T, Makowiecka A, Stopschinski BE, Schönichen A, Geyer M, Mannherz HG European Journal of Cell Biology 2015 Feb 94 101-113
Honors & Awards
- Alzheimer’s Association Clinician Scientist Fellowship Award
3 years (2023) - Aging Mind Fellow, The Aging Mind Foundation
(2018-2020) - Poster travel award for ANA meeting in 10/2018
(2018) - Carl B. and Florence E. King Foundation Award in Alzheimer’s Disease
(2017-2018) - Scholarship Clinical Research Program, University Hospital Aachen, Germany
(2015-2017) - Scholarship, exchange program between the Université François-Rabelais de Tours, France and the Ruhr-Universität Bochum, Germany
(2006-2007) - Scholar of the Studienstiftung des deutschen Volkes (German Academic Scholarship Foundation)
(2004-2010)
Professional Associations/Affiliations
- Center for Alzheimer's and Neurodegenerative Diseases (2023)
- Department of Neurology (2023)