Download Curriculum Vitae

Dr. Chahrour received her undergraduate degree in Biology from the American University of Beirut prior to attending the University of North Texas for a masters degree in Forensic Genetics. She obtained her Ph.D. in Molecular and Human Genetics from Baylor College of Medicine where she studied molecular mechanisms underlying Rett syndrome.

She joined Harvard Medical school and Boston Children's Hospital as a postdoctoral fellow and later as an instructor in the Division of Genetics and Genomics, where she focused on identifying genetic causes of autism spectrum disorders.

Dr. Chahrour joined the faculty at the McDermott Center for Human Genetics and the departments of Neuroscience and Psychiatry in 2015.

Research Interest

  • Autism spectrum disorders
  • Genetics of neurodevelopmental disorders
  • Ubiquitin proteasome pathway


Featured Publications LegendFeatured Publications

The diverse genetic landscape of neurodevelopmental disorders
Hu WF, Chahrour MH, Walsh CA Annual review of genomics and human genetics 2014 15 195-213
Synaptic, transcriptional and chromatin genes disrupted in autism
De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Cicek AE, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Shih-Chen F, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG, Coon H, Crawford EL, Curran SR, Dawson G, Duketis E, Fernandez BA, Gallagher L, Geller E, Guter SJ, Hill RS, Ionita-Laza J, Jimenz Gonzalez P, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei I, Lei J, Lehtimäki T, Lin CF, Ma'ayan A, Marshall CR, McInnes AL, Neale B, Owen MJ, Ozaki N, Parellada M, Parr JR, Purcell S, Puura K, Rajagopalan D, Rehnström K, Reichenberg A, Sabo A, Sachse M, Sanders SJ, Schafer C, Schulte-Rüther M, Skuse D, Stevens C, Szatmari P, Tammimies K, Valladares O, Voran A, Li-San W, Weiss LA, Willsey AJ, Yu TW, Yuen RK; DDD Study; Homozygosity Mapping Collaborative for Autism; UK10K Consortium, Cook EH, Freitag CM, Gill M, Hultman CM, Lehner T, Palotie A, Schellenberg GD, Sklar P, State MW, Sutcliffe JS, Walsh CA, Scherer SW, Zwick ME, Barett JC, Cutler DJ, Roeder K, Devlin B, Daly MJ, Buxbaum JD Nature 2014 515 7526 209-215
Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice
Heckman LD, Chahrour MH, Zoghbi HY eLife 2014 3 e02676
Ube3a/E6AP is involved in a subset of MeCP2 functions
Kim S, Chahrour M, Ben-Shachar S, Lim J Biochemical and biophysical research communications 2013 437 1 67-73
The autism sequencing consortium: large-scale, high-throughput sequencing in autism spectrum disorders
Buxbaum JD, Daly MJ, Devlin B, Lehner T, Roeder K, State MW; Autism Sequencing Consortium Neuron 2012 76 6 1052-1056
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY Nature 2010 468 7321 263-269


Featured Books Legend Featured Books

Autism spectrum disorders. In Genomic and personalized medicine

Yu TW, Coulter ME, Chahrour MH, Walsh CA (2012). Oxford, Academic Press

Professional Associations/Affiliations

  • International Rett Syndrome Foundation (2006-2009)
  • Society for Neuroscience (2006)
  • American Society of Human Genetics (2004)
  • Sigma Xi, The Scientific Research Society (2004)
  • American Academy of Forensic Sciences (2001-2004)
  • Association of Forensic DNA Analysts and Administrators (2001-2003)