Gary Hon is an Assistant Professor in the Department of Obstetrics and Gynecology, and he is a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences.
Dr. Hon studied computer science and molecular biology as an undergraduate at the University of California, Berkeley. As a graduate student under the direction of Dr. Bing Ren at the University of California, San Diego, he pioneered the use of epigenetic signatures to annotate regulatory elements in mammalian cells. Continuing his post-doctoral studies in Dr. Ren’s laboratory, Dr. Hon examined the dynamic epigenetic nature of regulatory elements in developmental and disease contexts.
Dr. Hon is intensely focused on unraveling the functions of the non-coding genome. A primary interest is to develop a comprehensive understanding of how the millions of non-coding regulatory elements encoded in mammalian genomes precisely coordinate gene expression in developmental and disease contexts. To accomplish this, he takes a systems biology approach: developing and employing integrative techniques at the interface of gene regulation, epigenetics, functional genomics, and bioinformatics.
- Developing (epi)genomic/bioinformatic tools to assess and predict the functions of regulatory elements
- Epigenetics in development and disease
- Global regulation of mammalian gene expression
- Non-coding genome function
- 5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation.
- Hon GC, Song CX, Du T, Jin F, Selvaraj S, Lee AY, Yen CA, Ye Z, Mao SQ, Wang BA, Kuan S, Edsall LE, Zhao BS, Xu GL, He C, Ren B Mol. Cell 2014 Sep
- Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues.
- Hon GC, Rajagopal N, Shen Y, McCleary DF, Yue F, Dang MD, Ren B Nat. Genet. 2013 Oct 45 10 1198-206
- Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
- Yu M, Hon GC, Szulwach KE, Song CX, Zhang L, Kim A, Li X, Dai Q, Shen Y, Park B, Min JH, Jin P, Ren B, He C Cell 2012 Jun 149 6 1368-80
- Distinct epigenomic landscapes of pluripotent and lineage-committed human cells.
- Hawkins RD, Hon GC, Lee LK, Ngo Q, Lister R, Pelizzola M, Edsall LE, Kuan S, Luu Y, Klugman S, Antosiewicz-Bourget J, Ye Z, Espinoza C, Agarwahl S, Shen L, Ruotti V, Wang W, Stewart R, Thomson JA, Ecker JR, Ren B Cell Stem Cell 2010 May 6 5 479-91
- Histone modifications at human enhancers reflect global cell-type-specific gene expression.
- Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, Harp LF, Ye Z, Lee LK, Stuart RK, Ching CW, Ching KA, Antosiewicz-Bourget JE, Liu H, Zhang X, Green RD, Lobanenkov VV, Stewart R, Thomson JA, Crawford GE, Kellis M, Ren B Nature 2009 May 459 7243 108-12
- Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing.
- Zhang L, Szulwach KE, Hon GC, Song CX, Park B, Yu M, Lu X, Dai Q, Wang X, Street CR, Tan H, Min JH, Ren B, Jin P, He C Nat Commun 2013 Feb 4 1517
- Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis.
- Chang KN, Zhong S, Weirauch MT, Hon G, Pelizzola M, Li H, Huang SS, Schmitz RJ, Urich MA, Kuo D, Nery JR, Qiao H, Yang A, Jamali A, Chen H, Ideker T, Ren B, Bar-Joseph Z, Hughes TR, Ecker JR Elife 2013 2 e00675
- Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.
- Yu M, Hon GC, Szulwach KE, Song CX, Jin P, Ren B, He C Nat Protoc 2012 Dec 7 12 2159-70
- CBX3 regulates efficient RNA processing genome-wide.
- Smallwood A, Hon GC, Jin F, Henry RE, Espinosa JM, Ren B Genome Res. 2012 Aug 22 8 1426-36
- Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer.
- Hon GC, Hawkins RD, Caballero OL, Lo C, Lister R, Pelizzola M, Valsesia A, Ye Z, Kuan S, Edsall LE, Camargo AA, Stevenson BJ, Ecker JR, Bafna V, Strausberg RL, Simpson AJ, Ren B Genome Res. 2012 Feb 22 2 246-58
Honors & Awards
- Cancer Prevention Research Institute of Texas First Time Faculty Recruitment Award