Download Curriculum Vitae

Gary Hon is an Assistant Professor in the Department of Obstetrics and Gynecology, and he is a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences.

Dr. Hon studied computer science and molecular biology as an undergraduate at the University of California, Berkeley. As a graduate student under the direction of Dr. Bing Ren at the University of California, San Diego, he pioneered the use of epigenetic signatures to annotate regulatory elements in mammalian cells. Continuing his post-doctoral studies in Dr. Ren’s laboratory, Dr. Hon examined the dynamic epigenetic nature of regulatory elements in developmental and disease contexts.

Dr. Hon is intensely focused on unraveling the functions of the non-coding genome. A primary interest is to develop a comprehensive understanding of how the millions of non-coding regulatory elements encoded in mammalian genomes precisely coordinate gene expression in developmental and disease contexts. To accomplish this, he takes a systems biology approach: developing and employing integrative techniques at the interface of gene regulation, epigenetics, functional genomics, and bioinformatics.

Research Interest

  • Developing (epi)genomic/bioinformatic tools to assess and predict the functions of regulatory elements
  • Epigenetics in development and disease
  • Global regulation of mammalian gene expression
  • Non-coding genome function


Featured Publications LegendFeatured Publications

Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing.
Zhang L, Szulwach KE, Hon GC, Song CX, Park B, Yu M, Lu X, Dai Q, Wang X, Street CR, Tan H, Min JH, Ren B, Jin P, He C Nat Commun 2013 Feb 4 1517
Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis.
Chang KN, Zhong S, Weirauch MT, Hon G, Pelizzola M, Li H, Huang SS, Schmitz RJ, Urich MA, Kuo D, Nery JR, Qiao H, Yang A, Jamali A, Chen H, Ideker T, Ren B, Bar-Joseph Z, Hughes TR, Ecker JR Elife 2013 2 e00675
Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.
Yu M, Hon GC, Szulwach KE, Song CX, Jin P, Ren B, He C Nat Protoc 2012 Dec 7 12 2159-70
CBX3 regulates efficient RNA processing genome-wide.
Smallwood A, Hon GC, Jin F, Henry RE, Espinosa JM, Ren B Genome Res. 2012 Aug 22 8 1426-36
Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer.
Hon GC, Hawkins RD, Caballero OL, Lo C, Lister R, Pelizzola M, Valsesia A, Ye Z, Kuan S, Edsall LE, Camargo AA, Stevenson BJ, Ecker JR, Bafna V, Strausberg RL, Simpson AJ, Ren B Genome Res. 2012 Feb 22 2 246-58

Honors & Awards

  • Cancer Prevention Research Institute of Texas First Time Faculty Recruitment Award