Alexandra Volk, M.D. Titles and Appointments Clinical Professor Schools Medical School | Graduate School Departments Pediatrics Graduate Programs Neuroscience You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Download Curriculum Vitae A. Paige Davis Volk graduated summa cum laude with a Bachelor’s Degree in Biochemistry and Chemistry from Cornell College. She obtained her M.D. from The University of Iowa Carver College of Medicine in 2000. Dr. Volk remained at The University of Iowa for her residency training in Pediatrics and her fellowship training in Pediatric Critical Care. She was recruited to join the faculty of The University of Iowa upon completion of her postgraduate training in 2006. Dr. Volk was appointed Assistant Professor in 2008 and served as Physician Leader for UIHC Schwartz Center Rounds from 2011 to 2015. She was Chief Pediatric Advisor to the Hospital Incident Commander for Disaster Management from 2010 to 2015 and Director of the Pediatric Critical Care Fellowship Program from 2014 to 2015. Dr. Volk was recruited to join the faculty at The University of Texas Southwestern Medical Center in 2015 and was promoted to Associate Professor. She is currently the Medical Director for the Children’s Medical Center PICU at the Plano campus. Dr. Volk also serves as the Medical Director for CMC Plano Respiratory Care Services and Physician Leader for CMC Plano Schwartz Center Rounds. In June 2016, Dr. Volk joined the Children’s Medical Center Plano Medical Executive Committee as Service Chief of Intensive Care and Inpatient Services. She is honored to care for the children of Texas. Education Medical School University of Iowa Carver College of Medicine (2000) Residency University of Iowa Hospitals and Clinics (2003), Pediatrics Fellowship University of Iowa Hospitals and Clinics (2006), Pediatric Critical Care Medicine Research Interest Cell volume regulation NADPH oxidase and the reactive oxygen species signaling Neutrophil chemotaxis Publications Impact of Weight-Based High-Flow Nasal Cannula Flow Limits on Intensive Care Unit Utilization in Bronchiolitis Moody GB, Shah S, Hasan A, Volk AP Respiratory care 2025 Oct 70 1240-1247 CPR during COVID-19: Use of Expert-driven Rapid Cycle Deliberate Practice to Implement PALS Guidelines Nichols B, McMichael AB, Volk AP, Bhaskar P, Bowens CD Pediatric Quality and Safety 2021 Jan 6 Creating the Subspecialty Pediatrics Investigator Network Author Collaboration at, Mink R, Schwartz A, Carraccio C, High P, Dammann C, McGann KA, Kesselheim J, Herman B, Pitts S, Baffa G, Herman B, Turner DA, Fussell J, High P, Hsu D, Stafford D, Aye T, Sauer C, Kesselheim J, Myers A, McGann K, Dammann C, Chess P, Mahan J, Weiss P, Curran M, Schwartz A, Carraccio C, Herman B, Mink R, Havalad V, Pinheiro J, Alderman E, Fuloria M, McCabe ME, Mehta J, Rivas Y, Rosenberg M, Doughty C, Hergenroeder A, Kale A, Lee-Kim YN, Rama JA, Steuber P, Volk P, Brion LP, Green M, Journeycake J, Yen K, Quigley R Journal of Pediatrics 2018 Jan 192 3-4.e2 Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment Ulland TK, Jain N, Hornick EE, Elliott EI, Clay GM, Sadler JJ, Mills KA, Janowski AM, Volk AP, Wang K, Legge KL, Gakhar L, Bourdi M, Ferguson PJ, Wilson ME, Cassel SL, Sutterwala FS Nature communications 2016 Oct 7 Interferon Regulatory factor 6 has a protective role in the host response to endotoxic shock Joly S, Rhea L, Volk P, Moreland JG, Dunnwald M PloS one 2016 Apr 11 Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk AP, Moreland JG Journal of Biological Chemistry 2012 Apr 287 12395-12404 Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-α is partially oxygen dependent Volk AP, Barber BM, Goss KL, Ruff JG, Heise CK, Hook JS, Moreland JG Journal of innate immunity 2011 Apr 3 298-314 ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change Volk AP, Heise CK, Hougen JL, Artman CM, Volk KA, Wessels D, Soll DR, Nauseef WM, Lamb FS, Moreland JG Journal of Biological Chemistry 2008 Dec 283 34315-34326 Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3 Moreland JG, Davis AP, Matsuda JJ, Hook JS, Bailey G, Nauseef WM, Lamb FS Journal of Biological Chemistry 2007 Nov 282 33958-33967 The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels Femling JK, Cherny VV, Morgan D, Rada B, Davis AP, Czirják G, Enyedi P, England SK, Moreland JG, Ligeti E, Nauseef WM, DeCoursey TE Journal of General Physiology 2006 Jun 127 659-672 Results 1-10 of 11 1 2 Next Last Honors & Awards National Compassionate CaregiverSchwartz Center (2018) Election to Society for Pediatric Research (2010) Above and Beyond AwardUniversity of Iowa Healthcare (2003) PEO Scholarship for International StudyUniversity of Iowa Healthcare (1998) Phi Beta KappaCornell College, Mt. Vernon, IA (1996) Mortar Board National Honor SocietyCornell College, Mt. Vernon, IA (1995-1996) Professional Associations/Affiliations American Academy of Pediatrics (2000) Midwest Society for Pediatric Research (2009) Mortar Board National Honor Society (1995-1996) Pediatric Academic Society (2008) Phi Beta Kappa Society (1996) Society for Leukocyte Biology (2004) Society of Critical Care Medicine (2003) University of Iowa Inflammation and Immune Diseases Center (2012)