Margaret Phillips, Ph.D.

Professor

Endowed Title: Carolyn R. Bacon Professorship in Medical Science and Education; Beatrice and Miguel Elias Distinguished Chair in Biomedical Science

Department: Pharmacology

Graduate Programs: Biological Chemistry, Molecular Biophysics

Biography

Margaret A. Phillips was born in Cleveland, Ohio in 1959. She received her undergraduate degree in Biochemistry from the University of California, Davis (1981) and her PhD in Pharmaceutical Chemistry from the University of California, San Francisco (1988), where she was also a postdoctoral fellow in the Dept. of Biochemistry (1988-1992).

Dr. Phillips is currently a Professor in the Department of Pharmacology at UT Southwestern, where her research focuses on biochemistry and drug discovery in parasitic protozoa. 

Education

Graduate School University of California (1988)

Research Interests

  • Drug design in protozoan parasites
  • Pyrimidine biosynthesis as a drug target in malarial parasites
  • Regulation and function of polyamine biosynthesis in African trypanosomes

Publications

Featured Publications Legend

Featured Publications

Genetic validation of Aminoacyl tRNA synthetases as drug targets in Trypanosoma brucei.

Kalidas S, Cestari I, Monnerat S, Li Q, Regmi S, Hasle N, Labaied M, Parsons M, Stuart K, Phillips MA Eukaryotic Cell 2014 Feb

A multiple aminoacyl-tRNA synthetase complex that enhances tRNA-aminoacylation in African trypanosomes.

Cestari I, Kalidas S, Monnerat S, Anupama A, Phillips MA, Stuart K Mol. Cell. Biol. 2013 Oct

Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme.

Xiao Y, Nguyen S, Kim SH, Volkov OA, Tu BP, Phillips MA Mol. Microbiol. 2013 Jun 88 5 846-61

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications.

Guler JL, Freeman DL, Ahyong V, Patrapuvich R, White J, Gujjar R, Phillips MA, Derisi J, Rathod PK PLoS Pathog. 2013 May 9 5 e1003375

Trypanosoma brucei S-Adenosylmethionine Decarboxylase N Terminus Is Essential for Allosteric Activation by the Regulatory Subunit Prozyme.

Velez N, Brautigam CA, Phillips MA J. Biol. Chem. 2013 Feb 288 7 5232-40

Results 1-10 of 15

Honors/Awards

  • Medicines for Malaria Venture
    Project of the Year (2010)
  • Burroughs Wellcome Fund Scholars Award in Molecular Parasitology
    (1999)
  • American Heart Association Established Investigator Award
    (1996)
  • Burroughs Wellcome Fund, New Investigator Award in Molecular Parasitology
    (1995)

Professional Associations/Affiliations

  • American Chemical Society
  • American Society of Biochemistry and Molecular Biology
  • American Society of Pharmacology and Experimental Therapeutics
  • American Society of Tropical Medicine and Hygiene