Biography

Margaret A. Phillips was born in Cleveland, Ohio in 1959. She received her undergraduate degree in Biochemistry from the University of California, Davis (1981) and her PhD in Pharmaceutical Chemistry from the University of California, San Francisco (1988), where she was also a postdoctoral fellow in the Dept. of Biochemistry (1988-1992).

Dr. Phillips is currently Professor and Chair of the Department of Biochemistry at UT Southwestern, where her research focuses on biochemistry and drug discovery in parasitic protozoa. 

Education

Undergraduate
University of California-Davis (1981), Biochemistry
Graduate School
University of California-Sfran (1988), Pharmaceutical Chemistry

Research Interest

  • Drug design in protozoan parasites
  • Pyrimidine metabolism in trypanosome and malaria parasites
  • Regulation and function of polyamine biosynthesis in African trypanosomes

Publications

Featured Publications LegendFeatured Publications

Identification of Trypanosoma brucei AdoMetDC inhibitors using a high-throughput mass spectrometry-based assay.
Volkov OA, Cosner CC, Brockway AJ, Kramer M, Booker M, Zhong S, Ketcherside A, Wei S, Longgood J, McCoy MK, Richardson TE, Wring SA, Peel M, Klinger JD, Posner BA, De Brabander JK, Phillips MA ACS Infect Dis 2017 Mar
Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.
McCarthy JS, Lotharius J, Rückle T, Chalon S, Phillips MA, Elliott S, Sekuloski S, Griffin P, Ng CL, Fidock DA, Marquart L, Williams NS, Gobeau N, Bebrevska L, Rosario M, Marsh K, Möhrle JJ Lancet Infect Dis 2017 Mar
Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidines targeting Plasmodium falciparum dihydroorotate dehydrogenase display potent and selective antimalarial activity.
Kokkonda S, Deng X, White KL, Coterón JM, Marco M, de Las Heras L, White J, El Mazouni F, Tomchick DR, Manjalanagara K, Rudra KR, Chen G, Morizzi J, Ryan E, Kaminsky W, Leroy D, Martínez-Martínez MS, Jimenez Diaz MB, Bazaga SF, Angulo-Barturen I, Waterson D, Burrows JN, Matthews D, Charman SA, Phillips MA, Rathod PK J. Med. Chem. 2016 Apr
GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.
Li Q, Leija C, Rijo-Ferreira F, Chen J, Cestari I, Stuart K, Tu BP, Phillips MA Mol. Microbiol. 2015 Jun
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.
Deng X, Kokkonda S, El Mazouni F, White J, Burrows JN, Kaminsky W, Charman SA, Matthews D, Rathod PK, Phillips MA J. Med. Chem. 2014 May
Genetic validation of Aminoacyl tRNA synthetases as drug targets in Trypanosoma brucei.
Kalidas S, Cestari I, Monnerat S, Li Q, Regmi S, Hasle N, Labaied M, Parsons M, Stuart K, Phillips MA Eukaryotic Cell 2014 Feb

Honors & Awards

  • Medicines for Malaria Venture
    Project of the Year (2010)
  • NIH Merit Award
    (2009-2019)
  • Burroughs Wellcome Fund Scholars Award in Molecular Parasitology
    (1999)
  • American Heart Association Established Investigator Award
    (1996)
  • Burroughs Wellcome Fund, New Investigator Award in Molecular Parasitology
    (1995)

Professional Associations/Affiliations

  • American Chemical Society
  • American Society of Biochemistry and Molecular Biology
  • American Society of Pharmacology and Experimental Therapeutics
  • American Society of Tropical Medicine and Hygiene