Dr. Petroll received his BS degree in Biomedical Engineering from Duke University in 1984, and his PhD in Biomedical Engineering from the University of Virginia in 1989. After two years at Georgetown University in the lab of Drs. James Jester and Dwight Cavanagh, he joined the faculty at UT Southwestern in 1991. He was promoted to professor in 2005, and became Chair of the Graduate Program in Biomedical Engineering in 2012.
Dr. Petroll’s laboratory applies engineering approaches and design principles to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to graduate students, medical students and post-docs. The main focus of Dr. Petroll’s research is cell mechanics and tissue engineering, in which multidimensional time-lapse imaging is used to investigate how the mechanical behavior of corneal fibroblasts is regulated by both biochemical and biophysical stimuli. He also has a longstanding interest in the development and application of in vivo confocal microscopy, which allows quantitative 3-D imaging of the cornea and has been used in numerous research and clinical studies on corneal wound healing, toxicity, development and infection.
|Undergraduate||Duke University (1984), Biomedical Engineering|
|Graduate School||University of Virginia Main Campus (1989), Biomedical Engineering|
- Cell Mechanics
- Confocal Microscopy
- Corneal Cell Biology
- Digital Imaging
- Wound Healing
- Corneal stromal cells use both high- and low-contractility migration mechanisms in 3-D collagen matrices.
- Kim A, Zhou C, Lakshman N, Petroll WM Exp. Cell Res. 2012 Apr 318 6 741-52
- Cell motility and mechanics in three-dimensional collagen matrices.
- Grinnell F, Petroll WM Annu. Rev. Cell Dev. Biol. 2010 Nov 26 335-61
- Rho Kinase Regulation of Fibroblast Migratory Mechanics in Fibrillar Collagen Matrices.
- Zhou C, Petroll WM Cell Mol Bioeng 2010 Mar 3 1 76-83
- Characterization of corneal keratocyte morphology and mechanical activity within 3-D collagen matrices.
- Lakshman N, Kim A, Petroll WM Exp. Eye Res. 2010 Feb 90 2 350-9
- Localized application of mechanical and biochemical stimuli in 3-D culture.
- Petroll WM, Ma L Dev. Dyn. 2008 Oct 237 10 2726-36
- Dynamic three-dimensional visualization of collagen matrix remodeling and cytoskeletal organization in living corneal fibroblasts.
- Petroll WM, Cavanagh HD, Jester JV Scanning 2004 Jan-Feb 26 1 1-10
- Direct, dynamic assessment of cell-matrix interactions inside fibrillar collagen lattices.
- Petroll WM, Ma L Cell Motil. Cytoskeleton 2003 Aug 55 4 254-64
- Direct correlation of collagen matrix deformation with focal adhesion dynamics in living corneal fibroblasts.
- Petroll WM, Ma L, Jester JV J. Cell. Sci. 2003 Apr 116 Pt 8 1481-91
- On-line 3-dimensional confocal imaging in vivo.
- Li J, Jester JV, Cavanagh HD, Black TD, Petroll WM Invest. Ophthalmol. Vis. Sci. 2000 Sep 41 10 2945-53
- Growth factor regulation of corneal keratocyte mechanical phenotypes in 3-D collagen matrices.
- Lakshman N, Petroll WM Invest. Ophthalmol. Vis. Sci. 2012 53 3 1077-86
Honors & Awards
- Fellow, Silver Level
Association for Research in Vision and Ophthalmology (2009)
- Senior Scientific Investigator Award
Research to Prevent Blindness (2008)
- Olga Keith Weiss Scholar Award
Research to Prevent Blindness (1999)
- Chair, Graduate Program in Biomedical Engineering (2012)
- American Society for Cell Biology
- Association for Research in Vision and Ophthalmology
- Biomedical Engineering Society