Meet Dr. Margaret Pearle
Kidney Stone Specialist

Holder of the:
Dr. Ralph C. Smith Distinguished Chair in Urologic Education

When kidney stones stump other physicians, those doctors depend on the expertise of Margaret Pearle, M.D., Ph.D., a urologist at UT Southwestern Medical Center who specializes in kidney stone treatment. She has the skill to handle the most complicated stone cases.

While Dr. Pearle says she likes the surgical challenges those difficult cases present, she also enjoys working with patients to manage kidney stones and developing preventive programs for those troubled with recurring stones.

"I'm able to help prevent patients from making stones, or at least reduce the rate at which they are making stones," she says.

I can bring relief to patients with stones."

Dr. Pearle has a joint appointment in Urology and the UT Southwestern Mineral Metabolism Center, which helps her create overall management strategies for her patients. A management plan for kidney stones includes analyzing blood and urine specimens to measure for substances that positively or negatively affect stone formation, and recommending diet changes and medication, if needed. 

A Texas Monthly Super Doctor, Dr. Pearle is one of the relatively few physicians in the area who offers percutaneous stone removal for complex cases that involve a large volume of stones. In that process, she passes a telescope through a small incision in the back directly into the kidney to fragment and remove stones.

In addition to her work with patients, Dr. Pearle chairs a guidelines panel of stone experts that recommends to practicing physicians preventive strategies for managing stones. She's also involved in clinical trials that compare different treatments for stones and that evaluate outcomes for surgical management of stones.

Clinical Interests


  • Kidney stones
  • Male & female ureteral strictures
  • Medical management of stones
  • Staghorn calculi
  • Stone prevention
  • Ureteral cancer, masses & tumors
  • Ureteral stones
  • Percutaneous nephrolithotomy
  • Lithotripsy
  • Ureteroscopy