Dr. Yingfei Wang obtained her Ph.D. degree in Neuroscience at the University of Magdeburg in Germany and completed her postdoctoral training at the Johns Hopkins School of Medicine. In December 2014, Dr. Wang became an Assistant Professor in the Department of Pathology and Neurology at UT Southwestern.
Dr. Wang studies the molecular and cellular mechanisms of neuronal cell death in neurologic diseases. The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in cell death through a caspase-independent manner after ischemia-reperfusion injury, glutamate excitotoxicity and various inflammatory responses, as well as neurodegenerative diseases. Dr. Wang uses a combination of tools, including epigenetics, bioinformatics, proteomics and mouse genetics, to study the cell signaling and regulation of PARP-1 dependent DNA damage and cell death in neurologic diseases. Her overall goals are to identify novel therapeutic targets and translate the knowledge to develop therapeutic strategies to prevent or treat neurologic diseases.
- Cell Death/Cell Survival
- DNA Damage
- Stroke/Acute brain injury
- A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
- Wang Y*, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim BW, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam T, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL*, Dawson TM* (* Corresponding Authors) Science 2016 Vol. 354, Issue 6308, 82, aa6872-1-13
- Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos).
- Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM Sci Signal 2011 4 167 ra20
- Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos.
- Wang Y, Dawson VL, Dawson TM Exp. Neurol. 2009 Aug 218 2 193-202
- Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos).
- Wang Y, Kim NS, Li X, Greer PA, Koehler RC, Dawson VL, Dawson TM J. Neurochem. 2009 Jul 110 2 687-96
- Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release.
- Yu SW, Wang Y, Frydenlund DS, Ottersen OP, Dawson VL, Dawson TM ASN Neuro 2009 1 5
- HIF repressors under chronic hypoxia.
- Luo W, Wang Y Aging (Albany NY) 2016 Mar
- PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia.
- Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL Oncotarget 2016 Feb
- PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility.
- Luo W, Lin B, Wang Y, Zhong J, O'Meally R, Cole RN, Pandey A, Levchenko A, Semenza GL Mol. Biol. Cell 2014 Sep 25 18 2788-96
- New synaptic and molecular targets for neuroprotection in Parkinson's disease.
- Calabresi P, Di Filippo M, Gallina A, Wang Y, Stankowski JN, Picconi B, Dawson VL, Dawson TM Mov. Disord. 2013 Jan 28 1 51-60
- Proteinase-activated receptors, nucleotide P2Y receptors, and µ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.
- Luo W, Wang Y, Reiser G J. Neurochem. 2011 Apr 117 1 71-81
The role of thrombin and thrombin receptors in the brain.. In Thrombin: Physiology and Disease
Luo W, Wang Y, Reiser G. (2008). Springer Verlag
Honors & Awards
- Darrell K Royal (DKR) Research Award
- UT TBI Pilot Grant
- UT Rising Star Award
- American Heart Association (AHA) National Scientist Development Grant Award
- NIH Pathway to Independence Award (Parent K99/R00)
- American Heart Association (AHA) Postdoctoral Fellowship Award
- Chinese Government Award for Outstanding Student Abroad
- Summa cum laude for Ph.D dissertation
- German Research Foundation DFG Scholarship
- Member of American Association for Cancer Research (AACR) (2015)
- Member of American Heart Association (AHA) (2012)
- Associate Faculty Member of Faculty of 1000 Biology (2011-2012)
- Member of Society for Neuroscience (2007)