Dr. Luis F. Parada is the Department Chair and holder of the Diana and Richard C. Strauss Distinguished Chair in Developmental Biology. He is also the Director of the Kent Waldrep Foundation Center for Basic Neuroscience Research. His laboratory uses genetic mouse models to study human disease including nervous system cancers, Neurofibromatosis, and autism. Dr. Parada obtained a B.S. from the University of Wisconsin and a Ph.D. in Biology from MIT. He was a Damon Runyon and Helen Hay Whitney Postdoctoral Fellow at the Pasteur Institute. From 1988 to 1994, he headed the Molecular Embryology Section at the NCI where he studied the Trk receptor tyrosine kinases. In 1994, Dr. Parada moved to the UT Southwestern Medical Center at Dallas as Director of the Center for Developmental Biology, and continued his studies on nerve cell survival and regeneration, eventually turning his attention to cancer biology. Currently, a main focus of the lab is investigation of the role of cancer stem cells in malignant brain tumors. He is an American Cancer Society Professor, and a Fellow of The National Academy of Sciences; The American Academy of Arts and Sciences; The Institute of Medicine; and The American Association for the Advancement of Science.
- University of Wisconsin-Madison (1979)
- Graduate School
- Massachusetts Institute of Technology (1985)
- Developmental Neurobiology
- Mouse Models of CNS Tumors
- The tumor suppressor CDKN3 controls mitosis.
- Nalepa G, Barnholtz-Sloan J, Enzor R, Dey D, He Y, Gehlhausen JR, Lehmann AS, Park SJ, Yang Y, Yang X, Chen S, Guan X, Chen Y, Renbarger J, Yang FC, Parada LF, Clapp W J. Cell Biol. 2013 Jun 201 7 997-1012
- Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.
- Takeuchi K, Gertner MJ, Zhou J, Parada LF, Bennett MV, Zukin RS Proc. Natl. Acad. Sci. U.S.A. 2013 Mar 110 12 4738-43
- CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors.
- Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, Parada LF Cell 2013 Feb
- Neurofibromatosis type 1: modeling CNS dysfunction.
- Gutmann DH, Parada LF, Silva AJ, Ratner N J. Neurosci. 2012 Oct 32 41 14087-93
- Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development.
- Li Y, Yui D, Luikart BW, McKay RM, Li Y, Rubenstein JL, Parada LF Proc. Natl. Acad. Sci. U.S.A. 2012 Sep 109 38 15491-6
- Malignant glioma: lessons from genomics, mouse models, and stem cells.
- Chen J, McKay RM, Parada LF Cell 2012 Mar 149 1 36-47
- Neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants.
- Li Y, Li Y, McKay RM, Riethmacher D, Parada LF J. Neurosci. 2012 Mar 32 10 3529-39
- Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis
- Amiri, A., Cho, W., Zhou, J., Birnbaum, S.G., Sinton, C.M., McKay, R.M., and Parada, L.F. Journal of Neuroscience 2012 32(17) 5880-5890
- A restricted cell population propagates glioblastoma growth following chemotherapy
- Chen, J., Li, Y., Yu, T-S., McKay, R.M., Burns, D.K., and Parada, L.F. Nature 2012 488 522-526
- Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.
- Kim TH, Song J, Alcantara Llaguno SR, Murnan E, Liyanarachchi S, Palanichamy K, Yi JY, Viapiano MS, Nakano I, Yoon SO, Wu H, Parada LF, Kwon CH PLoS ONE 2012 7 8 e42818
Honors & Awards
- National Academy of Sciences
- 2nd Friederich Von Recklinghausen Award
- Fellow American Association for the Advancement of Science
- American Academy of Arts and Sciences
- Institute of Medicine- NAS
- American Association for Cancer Research
- American Association for the Advancement of Science
- Intl. Society for Stem Cell Research
- Society for Developmental Biology
- Society for Neuroscience