Jim Collins received his BS in Biology from Southeast Missouri State University (2003) and PhD from Washington University in St. Louis (2008). He did postdoctoral work with Phillip Newmark (Howard Hughes Medical Institute) at the University of Illinois at Urbana-Champaign.
His research focuses on the basic biology parasitic flatworms called schistosomes. These parasites infect more than 200 million of the world's poorest people, causing morbidity that rivals global killers including Malaria and TB. Despite their devastating global impact, only a single drug is available to treat schistosome infection. As a postdoc Dr. Collins developed new functional genomic tools to study these worms and using these tools discovered a novel population of stem cells that are likely key to parasite survival inside their human host. By studying these stem cells, and applying large-scale functional genomic approaches, his work aims to develop new therapeutic avenues to combat these devastating parasites.
- Germ cells
- Parasite biology
- Stem cells
- Stem cell progeny contribute to the schistosome host-parasite interface.
- Collins JJ, Wendt GR, Iyer H, Newmark PA Elife 2016 Mar 5
- Adult somatic stem cells in the human parasite Schistosoma mansoni.
- Collins JJ, Wang B, Lambrus BG, Tharp ME, Iyer H, Newmark PA Nature 2013 Feb 494 7438 476-9
- It's no fluke: the planarian as a model for understanding schistosomes.
- Collins JJ, Newmark PA PLoS Pathog. 2013 9 7 e1003396
- An atlas for Schistosoma mansoni organs and life-cycle stages using cell type-specific markers and confocal microscopy.
- Collins JJ, King RS, Cogswell A, Williams DL, Newmark PA PLoS Negl Trop Dis 2011 5 3 e1009
- Genome-wide analyses reveal a role for peptide hormones in planarian germline development.
- Collins JJ, Hou X, Romanova EV, Lambrus BG, Miller CM, Saberi A, Sweedler JV, Newmark PA PLoS Biol. 2010 8 10 e1000509
- Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni.
- Wang B, Collins JJ, Newmark PA Elife 2013 2 e00768
- A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite.
- Chong T, Collins JJ, Brubacher JL, Zarkower D, Newmark PA Nat Commun 2013 4 1814
- Whole mount in situ hybridization methodology for Schistosoma mansoni.
- Cogswell AA, Collins JJ, Newmark PA, Williams DL Mol. Biochem. Parasitol. 2011 Jul-Aug 178 1-2 46-50