Research Interest

  • Age-related macular degeneration; inherited retinal dystrophies and degeneration; ocular protein misfolding diseases; stress-responsive signaling; chemical biology; drug discovery


Featured Publications LegendFeatured Publications

Differential tolerance of 'pseudo-pathogenic' tryptophan residues in calcium-binding EGF domains of short fibulin proteins.
Nguyen A, Hulleman JD Exp. Eye Res. 2015 Jan 130 66-72
The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.
Wang X, Cattaneo F, Ryno L, Hulleman J, Reixach N, Buxbaum JN J. Neurosci. 2014 May 34 21 7253-65
A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion.
Hulleman JD, Brown SJ, Rosen H, Kelly JW J Biomol Screen 2013 Jul 18 6 647-58
Translational attenuation differentially alters the fate of disease-associated fibulin proteins.
Hulleman JD, Balch WE, Kelly JW FASEB J. 2012 Nov 26 11 4548-60
Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1.
Madian AG, Hindupur J, Hulleman JD, Diaz-Maldonado N, Mishra VR, Guigard E, Kay CM, Rochet JC, Regnier FE Mol. Cell Proteomics 2012 Feb 11 2 M111.010892


Featured Books Legend Featured Books

Alpha-Synuclein self-assembly in Parkinson's disease: Insights from biophysical analyses. In Protein Misfolding in Biology and Disease

Rochet JC and Hulleman JD (2009). Trivandrum, India, Research Signpost