Research Interest

  • Age-related macular degeneration; inherited retinal dystrophies and degeneration; ocular protein misfolding diseases; stress-responsive signaling; chemical biology; drug discovery


Featured Publications LegendFeatured Publications

Differential tolerance of 'pseudo-pathogenic' tryptophan residues in calcium-binding EGF domains of short fibulin proteins.
Nguyen A, Hulleman JD Exp. Eye Res. 2015 Jan 130 66-72
The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.
Wang X, Cattaneo F, Ryno L, Hulleman J, Reixach N, Buxbaum JN J. Neurosci. 2014 May 34 21 7253-65
A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion.
Hulleman JD, Brown SJ, Rosen H, Kelly JW J Biomol Screen 2013 Jul 18 6 647-58
Translational attenuation differentially alters the fate of disease-associated fibulin proteins.
Hulleman JD, Balch WE, Kelly JW FASEB J. 2012 Nov 26 11 4548-60
Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1.
Madian AG, Hindupur J, Hulleman JD, Diaz-Maldonado N, Mishra VR, Guigard E, Kay CM, Rochet JC, Regnier FE Mol. Cell Proteomics 2012 Feb 11 2 M111.010892
Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration.
Hulleman JD, Kaushal S, Balch WE, Kelly JW Mol. Biol. Cell 2011 Dec 22 24 4765-75
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.
Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW Proc. Natl. Acad. Sci. U.S.A. 2009 Nov 106 44 18563-8


Featured Books Legend Featured Books

Alpha-Synuclein self-assembly in Parkinson's disease: Insights from biophysical analyses. In Protein Misfolding in Biology and Disease

Rochet JC and Hulleman JD (2009). Trivandrum, India, Research Signpost