Research Interest

  • Age-related macular degeneration; inherited retinal dystrophies and degeneration; ocular protein misfolding diseases; stress-responsive signaling; chemical biology; drug discovery

Publications

Featured Publications LegendFeatured Publications

A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture.
Zadoo S, Nguyen A, Zode G, Hulleman JD Invest. Ophthalmol. Vis. Sci. 2016 Apr 57 4 1939-1950
Differential tolerance of 'pseudo-pathogenic' tryptophan residues in calcium-binding EGF domains of short fibulin proteins.
Nguyen A, Hulleman JD Exp. Eye Res. 2015 Jan 130 66-72
ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein.
Chen JJ, Genereux JC, Qu S, Hulleman JD, Shoulders MD, Wiseman RL Chem. Biol. 2014 Nov 21 11 1564-74
The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.
Wang X, Cattaneo F, Ryno L, Hulleman J, Reixach N, Buxbaum JN J. Neurosci. 2014 May 34 21 7253-65

Books

Featured Books Legend Featured Books

Alpha-Synuclein self-assembly in Parkinson's disease: Insights from biophysical analyses. In Protein Misfolding in Biology and Disease

Rochet JC and Hulleman JD (2009). Trivandrum, India, Research Signpost