Biography

Laura Banaszynski is an Assistant Professor in the Department of Obstetrics and Gynecology and Children's Research Institute. She is a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences.

Dr. Banaszynski received her BS in Chemistry from The University of Notre Dame in 2000. She completed her PhD in Chemical & Systems Biology with Tom Wandless at Stanford University in 2007. From 2008-2014, she was a Damon Runyon postdoctoral fellow with David Allis at The Rockefeller University. In 2015, Dr. Banaszynski joined the faculty of UT Southwestern. 

Dr. Banaszynski studies epigenetic contributions to gene expression and genome stability in mammalian systems. Her research focuses on the dynamic regulation of chromatin states at both coding and non-coding regions including the influence of histone variant incorporation on histone post-translational modification states. Her long-term goal is to improve our understanding of the chromatin-based mechanisms regulating fundamental cell-fate decisions in pluripotency and differentiation that are essential to our understanding of developmental processes.

Research Interest

  • Chromatin Biology
  • Developmental Gene Regulation
  • Histone Variants
  • Stem Cells

Publications

Featured Publications LegendFeatured Publications

Genome editing a mouse locus encoding a variant histone, H3.3B, to report on its expression in live animals.
Wen D, Noh KM, Goldberg AD, Allis CD, Rosenwaks Z, Rafii S, Banaszynski LA Genesis 2014 Dec 52 12 959-66
H3.3 replacement facilitates epigenetic reprogramming of donor nuclei in somatic cell nuclear transfer embryos.
Wen D, Banaszynski LA, Rosenwaks Z, Allis CD, Rafii S Nucleus 2014 Sep-Oct 5 5 369-75
Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma.
Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD Science 2013 Mar
Analysis of histones and chromatin in Xenopus laevis egg and oocyte extracts.
Banaszynski LA, Allis CD, Shechter D Methods 2010 May 51 1 3-10

Honors & Awards

  • Cancer Prevention Research Institute of Texas First Time Faculty Recruitment Award
    (2014-2018)
  • American Chemical Society Nobel Laureate Signature Award for Graduate Education in Chemistry
    (2009)
  • Damon Runyon Cancer Research Foundation Postdoctoral Fellowship
    Angelo Family Fellow (2008-2011)