Biography

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Marc Diamond, M.D., is a native of Berkeley, California. He graduated from Princeton University in 1987 with an A.B. in History. He entered the UCSF School of Medicine in 1987, and he carried out research on transcriptional regulation by the glucocorticoid receptor for two years with Keith Yamamoto, Ph.D. as a Howard Hughes Medical Student Research Fellow. Dr. Diamond received his M.D. from UCSF in 1993 where he also completed an internship, residency, and chief residency in Neurology in 1997. He completed a postdoctoral fellowship in the laboratory of Dr. Yamamoto until 2001, working on two polyglutamine diseases—spinobulbar muscular atrophy and Huntington’s disease.

 Dr. Diamond joined the faculty of the Department of Neurology at UCSF from 2002-2009, before moving to Washington University in St. Louis in 2009, as the David Clayson Professor of Neurology. He joined the faculty of UT Southwestern Medical Center in 2014 as the founding director of the Center for Alzheimer’s and Neurodegenerative Diseases. He is interested in neurodegenerative diseases linked to protein aggregation, and the role of prion mechanisms in the normal and abnormal physiology of protein amyloids.

Education

Graduate School
Princeton University (1987), History
Medical School
University of California-San F (1993), Medicine

Research Interest

  • Cell and Molecular Biology
  • Neurodegenerative Diseases
  • Neuroscience
  • Prion Biology

Publications

Featured Publications LegendFeatured Publications

FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples.
Furman JL, Diamond MI Methods Mol. Biol. 2017 1523 349-359
Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.
Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI Neuron 2016 Nov 92 4 796-812
Neuronal activity enhances tau propagation and tau pathology in vivo.
Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA, Herman M, Nahmani E, Emrani S, Figueroa YH, Diamond MI, Clelland CL, Wray S, Duff KE Nat. Neurosci. 2016 Jun
Prions and Protein Assemblies that Convey Biological Information in Health and Disease.
Sanders DW, Kaufman SK, Holmes BB, Diamond MI Neuron 2016 Feb 89 3 433-48
Distinct therapeutic mechanisms of Tau antibodies: promoting microglial clearance vs. blocking neuronal uptake.
Funk KE, Mirbaha H, Jiang H, Holtzman DM, Diamond MI J. Biol. Chem. 2015 Jun
Subcellular Localization and Ser-137 Phosphorylation Regulate Tumor-Suppressive Activity of Profilin-1.
Diamond MI, Cai S, Boudreau A, Carey CJ, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J J. Biol. Chem. 2015 Feb
The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.
Wobst HJ, Sharma A, Diamond MI, Wanker EE, Bieschke J FEBS Lett. 2015 Jan 589 1 77-83
Proteopathic tau seeding predicts tauopathy in vivo.
Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI Proc. Natl. Acad. Sci. U.S.A. 2014 Sep
Distinct tau prion strains propagate in cells and mice and define different tauopathies.
Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI Neuron 2014 Jun 82 6 1271-88
Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.
Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM Neuron 2013 Oct 80 2 402-14

Honors & Awards

  • Distinguished Chair
    Brain Injury and Repair (2014)
  • Scholar-Innovator Award
    Harrington (2012)
  • Foundation Award
    Ruth K. Broad (2010)
  • Endowed Chari
    David Clayson Professor of Neurology (2009)
  • Leadership Award
    Huntington's Disease Society of America (2007)
  • Sandler Opportunity Award
    (2007)