Biography

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Jian Xu received his Ph.D. with Dr. Stephen Smale from UCLA, where he studied epigenetic regulation of stem cell pluripotency. Upon completion of his Ph.D. training in 2008, he earned a Helen Hay Whitney Foundation postdoctoral fellowship and joined Dr. Stuart Orkin’s laboratory at Boston Children’s Hospital, Howard Hughes Medical Institute. In 2012, he became an instructor in pediatric hematology-oncology at Harvard Medical School. In 2014, Dr. Xu received a first-time investigator award from the Cancer Prevention and Research Institute of Texas and joined the faculty of the Children’s Medical Center Research Institute (CRI) at UT Southwestern as an Assistant Professor in Pediatrics.

The Xu lab is focuses on blood cell development and how abnormalities can cause cancers such as childhood leukemia. They seek to advance our understanding of the basic principles of gene regulation, particularly the mechanisms that control chromatin modifying complexes (e.g. Polycomb regulators) and non-coding regulatory elements (e.g. transcriptional enhancers), in normal and neoplastic blood cell development. Their studies promise to provide critical insights into developing novel therapeutic approaches for target-based cancer interventions.

Xu Laboratory

Education

Undergraduate
Fudan University (2000), Biochemistry
Graduate School
University of California UCLA (2017), Molecular Biology

Research Interest

  • Epigenetics of blood stem cell development and malignancies
  • Functional Genomics and Bioinformatics
  • Gene Expression and Regulation
  • Hematopoiesis and leukemogenesis
  • Non-Coding Regulatory Genome

Publications

Featured Publications LegendFeatured Publications

Honors & Awards

  • American Society of Hematology Scholar Award - Junior Faculty
    (2015)
  • CPRIT Scholar in Cancer Research
    (2014)
  • New Investigator Award, American Cancer Society/UT Southwestern
    (2014)
  • NIH/NIDDK Career Development Award (K01)
    (2011)
  • American Society of Hematology (ASH) Merit Award
    (2010)
  • American Society of Hematology (ASH) Merit Award
    (2009)
  • Helen Hay Whitney Foundation-HHMI Post-Doctoral Fellowship
    (2009)
  • California Institute for Regenerative Medicine (CIRM) Pre-Doctoral Fellowship
    (2007)

Professional Associations/Affiliations

  • International Society of Experimental Hematology (2017)
  • International Society for Stem Cell Research (2014)
  • American Society of Hematology (2008)