Jerry Niederkorn, Ph.D.

• Biology, Immunology and Therapy of Acanthamoeba Keratitis
• Immunobiology of Autoimmune Dry Eye Disease
• Immunobiology of Corneal Allografts
• Immunological Modulation of Ocular Tumor Metastases
• Transplant and Tumor Rejection Processes within the Eye

 Featured Publications

Induction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation.

Neelam S, Mellon J, Wilkerson A, Niederkorn JY Invest. Ophthalmol. Vis. Sci. 2018 Sep 59 11 4738-4747

Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models?.

Neelam S, Niederkorn JY Yale J Biol Med 2017 Jun 90 2 261-268

Effect of Corneal Nerve Ablation on Immune Tolerance Induced by Corneal Allografts, Oral Immunization, or Anterior Chamber Injection of Antigens.

Mo J, Neelam S, Mellon J, Brown JR, Niederkorn JY Invest. Ophthalmol. Vis. Sci. 2017 Jan 58 1 137-148

Growth and Metastasis of Intraocular Tumors in Aged Mice.

Han Z, Brown JR, Niederkorn JY Invest. Ophthalmol. Vis. Sci. 2016 May 57 6 2366-76

Natural Killer T Cells Contribute to Neutrophil Recruitment and Ocular Tissue Damage in a Model of Intraocular Tumor Rejection.

Ligocki AJ, Niederkorn JY Invest. Ophthalmol. Vis. Sci. 2016 Mar 57 3 813-23

Role of interferon-? and cytotoxic T lymphocytes in intraocular tumor rejection.

Ligocki AJ, Brown JR, Niederkorn JY J. Leukoc. Biol. 2015 Nov

Advances on Non-CD4 + Foxp3+ T Regulatory Cells: CD8+, Type 1, and Double Negative T Regulatory Cells in Organ Transplantation.

Ligocki AJ, Niederkorn JY Transplantation 2015 Jul

Immunology of Corneal Allografts: Insights from Animal Models.

Niederkorn JY J Clin Exp Ophthalmol 2015 Jun 6 3

Severing Corneal Nerves in One Eye Induces Sympathetic Loss of Immune Privilege and Promotes Rejection of Future Corneal Allografts Placed in Either Eye.

Paunicka KJ, Mellon J, Robertson D, Petroll M, Brown JR, Niederkorn JY Am. J. Transplant. 2015 Apr

NKT cells act through third party bone marrow-derived cells to suppress NK cell activity in the liver and exacerbate hepatic melanoma metastases.

Sadegh L, Chen PW, Brown JR, Han Z, Niederkorn JY Int. J. Cancer 2015 Feb

• Endowment
  Royal C. Miller Chair in Age-Related Macular Degeneration Research (2011)
• Vice Chair, Research
  Department of Ophthalmology (2011)
• Visiting Professor
  Zhongshan Ophthalmic Center, Sun Yat-sen University, (2007)
• Endowment
  George A. and Nancy P. Shutt Professorship in Medical Science (1995)
• PI
  3 NIH R01 Research Grants (0)
• PI
  NIH CORE Grant (0)

• Editorial Board , American Journal of Transplantation
• Editorial Board, Current Eye Research
• Editorial Board, Investigative Ophthalmology & Visual Sciences
• Immunology Graduate Program