Dr. Rajasekaran received his graduate degree from the University of Madras, India.  After completing his postdoctoral training at the University of Virginia, Charlottesville, he joined the faculty at UT Southwestern Medical Center as a member of the Rare Brain Disorders Program.  Dr. Rajasekaran's long term research objective is to understand how GABAergic neurotransmission orchestrates intercellular communication among neurons and how neural bioenergetics influences these processes, with the ultimate goal to develop therapies to prevent or abort rapidly evolving neuropathological conditions such as status epilepticus and traumatic brain injury as well as chronic conditions associated with metabolic encephalopathies.  A neuropharmacologist and electrophysiologist by training, Dr. Rajasekaran is passionate about epilepsy research and his research has been supported by grants from the Epilepsy Foundation of America and the American Epilepsy Society.


Research Interest

  • Feedforward Inhibition
  • Mechanisms of epileptogenesis
  • Status epilepticus
  • Synaptic plasticity


Featured Publications LegendFeatured Publications

Enhanced AMPA receptor-mediated neurotransmission on CA1 pyramidal neurons during status epilepticus.
Joshi S, Rajasekaran K, Sun H, Williamson J, Kapur J Neurobiol. Dis. 2017 Apr
Oxidation of [U-(13) C]glucose in the human brain at 7T under steady state conditions.
Cheshkov S, Dimitrov IE, Jakkamsetti V, Good L, Kelly D, Rajasekaran K, DeBerardinis RJ, Pascual JM, Sherry AD, Malloy CR Magn Reson Med 2017 Jan
Neurosteroid-sensitive d-GABAA receptors: A role in epileptogenesis?
Joshi S, Rajasekaran K, Williamson J, Kapur J Epilepsia 2017 58 3 494-504
Increased excitability and excitatory synaptic transmission during in vitro ischemia in the neonatal mouse hippocampus.
Zanelli SA, Rajasekaran KK, Grosenbaugh DK, Kapur J Neuroscience 2015 Sep
Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal.
Joshi S, Rajasekaran K, Hawk KM, Brar J, Ross BM, Tran CA, Chester SJ, Goodkin HP Epilepsia 2015 Aug
Receptor trafficking hypothesis revisited: Plasticity of AMPA receptors during established status epilepticus.
Rajasekaran K, Joshi S, Kozhemyakin M, Todorovic MS, Kowalski S, Balint C, Kapur J Epilepsia 2013 Sep 54 Suppl 6 14-6
GABAergic transmission in temporal lobe epilepsy: the role of neurosteroids.
Joshi S, Rajasekaran K, Kapur J Exp. Neurol. 2013 Jun 244 36-42
Somatostatin type-2 receptor activation inhibits glutamate release and prevents status epilepticus.
Kozhemyakin M, Rajasekaran K, Todorovic MS, Kowalski SL, Balint C, Kapur J Neurobiol. Dis. 2013 Jun 54 94-104


Featured Books Legend Featured Books

Neurosteroid modulation of GABAA receptor mediated synaptic transmission in an animal model of temporal lobe epilepsy. In Encyclopedia of Basic Epilepsy Research

Rajasekaran K, Mtchedlishvili Z, Sun C, Kapur J. (2009). USA, Elsevier

The midline thalamic nuclei in the mesial temporal lobe epilepsy syndrome. In Pan-Brain Abnormal Neural Network in Epilepsy

Rajasekaran K, Bertram EH. (2009). India, Research Signpost

Causes of status epilepticus. In The Causes of Epilepsy: Common and uncommon causes in adults and children

Rajasekaran K, Goodkin HP (2011 Jun). UK, Cambridge

Honors & Awards

  • Research Grants Program
    American Epilepsy Society (2014)
  • Best Research Poster
    3rd London-Innsbruck Colloquium on Acute Seizures & Status Epilepticus (2011)
  • Postdoctoral Fellowship
    Epilepsy Foundation of America (2009)
  • Dr. D.M. Kar Prize
    Indian Academy of Neurosciences (2003)
  • Senior Research Fellowship
    Council of Scientific & Industrial Research, Government of India (2003)
  • Dr. D.M. Kar Prize
    Indian Academy of Neurosciences (1998)
  • Senior Research Fellowship
    Lady Tata Memorial Trust, India (1998)

Professional Associations/Affiliations

  • American Epilepsy Society (2006)
  • Society for Neuroscience (2005)
  • Indian Academy of Neurosciences (1999)