Orson Moe, M.D.


Endowed Title: The Charles Pak Distinguished Chair in Mineral Metabolism; Donald W. Seldin Professorship in Clinical Investigation

Department: Internal Medicine, Physiology

Graduate Programs: Integrative Biology


Orson Moe received his medical degree from the University of Toronto and is currently Professor of Internal Medicine and Physiology at the University of Texas Southwestern Medical Center. He is the Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research. He is also a member of the Nephrology Division at Southwestern. Dr. Moe is the holder of the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. In addition to editing Current Opinions of Nephrology and Hypertension, Dr. Moe also serves on the editorial board of the American Journal of Physiology, Journal of the American Society of Nephrology, and Initial Review Group at the National Institutes of Health Center for Scientific Review. Dr. Moe is currently a member of the American Society of Clinical Research, American Association of Physicians, American Society of Nephrology, American Physiologic Society, and Biophysical Society.


Medical School University of Toronto Faculty of Medicine (1982)
Internship St. Michael's Hospital (1983), Medical/surgical
Residency St. Michael's Hospital (1986), Internal Medicine
Fellowship St. Michael's Hospital (1987), Nephrology
Fellowship UT Southwestern Medical Center (1990), Nephrology

Specialty Areas

Clinical Interests

  • Chronic Kidney Disease Bone & Mineral Problems
  • Congenital Tubular Disease
  • Electrolyte Abnormalities & Disorders
  • Kidney Stones

Research Interests

  • Epithelial Biology
  • Ion Transport
  • Metabolism


Featured Publications Legend

Featured Publications

Nephrolithiasis-associated bone disease: pathogenesis and treatment options

Sakhaee K, Maalouf N, Pasch A, Kumar R, Moe OW Kidney International February 2011 79 393-402

Klotho deficiency causes vascular calcificiation in chronic kidney disease

Hu MC, Shi, M, Zhang J, Quinones H, Griffith C, Kuro-o M, Moe OW J Am Soc Nephrology January 2011 22 124-36

Posing the question again: Does chronic uric acid nephropothy exist? (Commentary)

Moe OW American Society of Nephrology September 2010 21 395-397

Metabolic basis for low urine pH in type 2 diabetes mellitus

Maalouf N, Cameron MA, Moe OW, Sakhaee K Clin J Am Soc Nephrology April 2010 5 1277-81

Acute regulation of renal Na+/H+ exchanger NHE3 by dopamine: Role of protein phosphatase 2A

Bobulescu IA, Qui?ones H, Gisler SM, Di Sole F, Shi M, Hu MC, Zhang J, Fuster DG, Wright N, Mumby M, Moe OW American Journal of Physiology February 2010 298 F1205-1213

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  • Outstanding Freshman Teacher
    1st yr medical students (2011)
  • Outstanding Freshman Teacher
    1st yr medical students (2006)
  • National Kidney Foundation of Canada
    Recipient of Research Fellowship (1987)

Professional Associations/Affiliations

  • Fellow, Royal College of Physicians of Canada
  • Member, American Physiologic Society
  • Member, American Society of Clinical Investigation
  • Member, American Society of Nephrology
  • Member, National Kidney Foundation