University of Tokyo (1982), Pharmacology
Graduate School
University of Tokyo (1992), Pharmacology

Research Interest

  • Antiphospholipid Syndrome
  • Insulin resistance and endothelial dysfunction
  • Vascular Biology and Atherosclerosis


Featured Publications LegendFeatured Publications

ApoE Receptor 2 mediates trophoblast dysfunction and pregnancy complications induced by antiphospholipid antibodies in mice.
Ulrich V, Gelber SE, Vukelic M, Sacharidou A, Herz J, Urbanus RT, de Groot PG, Natale DR, Harihara A, Redecha P, Abrahams VM, Shaul PW, Salmon JE, Mineo C Arthritis & rheumatology (Hoboken, N.J.) 2015 Oct
IgG Receptor Fc?RIIB Plays a Key Role in Obesity-Induced Hypertension.
Sundgren NC, Vongpatanasin W, Boggan BM, Tanigaki K, Yuhanna IS, Chambliss KL, Mineo C, Shaul PW Hypertension 2015 Feb 65 2 456-62
Fc? Receptors and Ligands and Cardiovascular Disease.
Tanigaki K, Sundgren N, Khera A, Vongpatanasin W, Mineo C, Shaul PW Circ. Res. 2015 Jan 116 2 368-384
PDZK1 Prevents Neointima Formation via Suppression of Breakpoint Cluster Region Kinase in Vascular Smooth Muscle.
Lee WR, Sacharidou A, Behling-Kelly E, Oltmann SC, Zhu W, Ahmed M, Gerard RD, Hui DY, Abe J, Shaul PW, Mineo C PLoS ONE 2015 10 4 e0124494
Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.
Ulrich V, Konaniah ES, Lee WR, Khadka S, Shen YM, Herz J, Salmon JE, Hui DY, Shaul PW, Mineo C J Am Heart Assoc 2014 Oct 3 5 e001369
Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.
Ulrich V, Konaniah ES, Herz J, Gerard RD, Jung E, Yuhanna IS, Ahmed M, Hui DY, Mineo C, Shaul PW Proc. Natl. Acad. Sci. U.S.A. 2014 Sep 111 37 13493-8
The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha.
Umetani M, Ghosh P, Ishikawa T, Umetani J, Ahmed M, Mineo C, Shaul PW Cell Metab. 2014 Jun
Bazedoxifene and Conjugated Estrogen Prevent Diet-induced Obesity, Hepatic Steatosis and Type 2 Diabetes in Mice Without Impacting the Reproductive Tract.
Barrera J, Chambliss KL, Ahmed M, Tanigaki K, Thompson B, McDonald JG, Mineo C, Shaul PW Am. J. Physiol. Endocrinol. Metab. 2014 Jun
27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth.
Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW Cell Rep 2013 Nov 5 3 637-45
Inhibition of nitric oxide and antiphospholipid antibody-mediated thrombosis.
Mineo C Curr Rheumatol Rep 2013 May 15 5 324