Chieko Mineo, Ph.D.

Dr. Chieko Mineo received both her B.S and Ph.D. in Pharmacology from University of Tokyo. She received post-doctoral training in Cell Biology at the University of Texas Southwestern Medical Center.

Dr. Mineo joined the faculty in the Department of Pediatrics at the University of Texas Southwestern Medical Center in 2002. She is a member of the Integrative Biology Graduate Program in the Division of Basic Science. 

Undergraduate

University of Tokyo (1982), Pharmacology

Graduate School

University of Tokyo (1992), Pharmacology

• Antiphospholipid Syndrome
• Insulin resistance and endothelial dysfunction
• Vascular Biology and Atherosclerosis

Featured Publications

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.

Huang L, Chambliss KL, Gao X, Yuhanna IS, Behling-Kelly E, Bergaya S, Ahmed M, Michaely P, Luby-Phelps K, Darehshouri A, Xu L, Fisher EA, Ge WP, Mineo C, Shaul PW, Nature 2019 Apr

Super-Resolution Ultrasound Imaging of Skeletal Muscle Microvascular Dysfunction in an Animal Model of Type 2 Diabetes.

Ghosh D, Peng J, Brown K, Sirsi S, Mineo C, Shaul PW, Hoyt K J Ultrasound Med 2019 Jan

Selective Non-nuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.

Selvaraj UM, Zuurbier K, Whoolery C, Plautz EJ, Chambliss KL, Kong X, Zhang S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW, Stowe AM Endocrinology 2018 Sep

Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.

Sacharidou A, Chambliss KL, Ulrich V, Salmon JE, Shen YM, Herz J, Hui DY, Terada LS, Shaul PW, Mineo C Blood 2018 Mar

Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells.

Morel E, Ghezzal S, Lucchi G, Truntzer C, Pais de Barros JP, Simon-Plas F, Demignot S, Mineo C, Shaul PW, Leturque A, Rousset M, Carrière V Biochim. Biophys. Acta 2018 Feb 1863 2 199-211

Hyposialylated IgG activates endothelial IgG receptor Fc?RIIB to promote obesity-induced insulin resistance.

Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C J. Clin. Invest. 2017 Nov

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.

Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J Nat. Med. 2017 Jun

New Insights in the Pathophysiology of Antiphospholipid Syndrome.

Sacharidou A, Shaul PW, Mineo C Semin. Thromb. Hemost. 2017 Jan

Non-Nuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.

Chambliss KL, Barrera J, Umetani M, Umetani J, Kim SH, Madak-Erdogan Z, Huang L, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW Endocrinology 2016 Aug en20151629

Endothelial Fc? Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice.

Tanigaki K, Chambliss KL, Yuhanna IS, Sacharidou A, Ahmed M, Atochin DN, Huang PL, Shaul PW, Mineo C Diabetes 2016 Apr

 Featured Books

Mechanisms of Antiphospholipid Antibody-Mediated Pregnancy Morbidity. In Erkan D, Lockshin MD, eds. Antiphospholipid Syndrome: Current Research Highlights and Clinical Insights.

Salmon JE, Mineo C, Giles I, Chamley LW, Meroni PL, Abrahams VM. (2017). Springer International Publishing; 117-146.

Regulation of eNOS in Caveolae. In Jasmin J, Frank P, Lisanti MP, eds. Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms.

Mineo C, Shaul PW. (2012). New York: Springer; 51-62.

• American Diabetes Association (2006)
• American Heart Association (2004)