Michael Sebert, M.D., is a graduate of Duke University and the Stanford University School of Medicine. He completed his internship and residency in pediatrics as well as his fellowship in pediatric infectious diseases at the Children's Hospital of Philadelphia.

Dr. Sebert's clinical interests include infection prevention and healthcare-associated infections. He focuses his research on microbial evolution, pathogen transmission and hospital epidemiology.

He is presently an Associate Professor of Pediatrics and serves as the Medical Director for Infection Prevention and Control at Children's Health.


Medical School
Stanford University School of Medicine (1995)
Children's Hospital of Philadelphia (1998), Pediatrics
Children's Hospital of Philadelphia (2002), Pediatric Infectious Diseases

Specialty Areas

Research Interest

  • Bacterial pathogenesis
  • Genomic epidemiology
  • Hospital epidemiology
  • Microbial evolution
  • Pathogen transmission
  • Streptococcus pneumoniae


Featured Publications LegendFeatured Publications

Competence in Streptococcus pneumoniae is a response to an increasing mutational burden.
Gagne AL, Stevens KE, Cassone M, Pujari A, Abiola OE, Chang DJ, Sebert ME PLoS ONE 2013 8 8 e72613
The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide.
Cassone M, Gagne AL, Spruce LA, Seeholzer SH, Sebert ME J. Biol. Chem. 2012 Nov 287 46 38449-59
Frequent beneficial mutations during single-colony serial transfer of Streptococcus pneumoniae.
Stevens KE, Sebert ME PLoS Genet. 2011 Aug 7 8 e1002232
Competence in Streptococcus pneumoniae is regulated by the rate of ribosomal decoding errors.
Stevens KE, Chang D, Zwack EE, Sebert ME MBio 2011 2 5
Bacteriocin activity of Streptococcus pneumoniae is controlled by the serine protease HtrA via posttranscriptional regulation.
Dawid S, Sebert ME, Weiser JN J. Bacteriol. 2009 Mar 191 5 1509-18
An outbreak of Serratia marcescens bacteremia after general anesthesia.
Sebert ME, Manning ML, McGowan KL, Alpern ER, Bell LM Infect Control Hosp Epidemiol 2002 Dec 23 12 733-9


Featured Books Legend Featured Books

Honors & Awards

  • Dean's Award for Research, Stanford University School of Medicine

Professional Associations/Affiliations

  • Society for Healthcare Epidemiology of America (2014)
  • Society for Pediatric Research (2009)
  • American Academy of Pediatrics (2005)
  • Infectious Disease Society of America (2003)
  • American Society for Microbiology (2000)