Carole Mendelson, Ph.D.

Professor

Department: Biochemistry, Obstetrics & Gynecology

Graduate Programs: Biological Chemistry, Cell Regulation, Integrative Biology

Biography

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Carole Mendelson received a B.S. in Biology from the City College of New York and a Ph.D. in Zoology from Rutgers University, New Brunswick, N.J. She spent five years as a postdoctoral and then Staff Fellow at the National Institutes of Health in Bethesda, Maryland. She joined the faculty of UT Southwestern in 1978. Research in the Mendelson laboratory is focused on reproductive and perinatal biology and includes: (1) genetic and epigenetic mechanisms in the developmental, hormonal and tissue-specific regulation of the gene encoding SP-A, the major protein of pulmonary surfactant; (2) transcriptional regulation of aromatase (CYP19) gene expression in estrogen-producing tissues and in pathologic states, including endometriosis, cancer and preeclampsia; (3) regulatory mechanisms involved in maintenance of uterine quiescence during pregnancy and activation of contractile genes leading to term and pre-term labor. Dr. Mendelson’s research is funded by the National Institutes of Health and March of Dimes Foundation. She held an NIH MERIT Award from 1998 – 2008.

Dr. Mendelson served as a member of the Board of Scientific Counselors for the National Heart, Lung and Blood Institute, NIH, and currently chairs the Reproductive Scientist Development Program Selection Committee and is a member of the Basil O’Connor Starter Scholar Research Award Advisory Committee. She is active within The Endocrine Society (TES), in which she has chaired a number of committees and served as a member of Council and as Vice President for Basic Scientists from 2008 – 2011. She also has been active in several committees that support the career advancement of women in science and medicine. She was president of Women in Endocrinology of TES. Within UT Southwestern, she co-chairs the Women in Science and Medicine Advisory Committee and chairs the Committee on the Advancement of Women.

Education

Undergraduate City College of New York (1964), Biology
Graduate School Rutgers University New Brunswick (1970), Zoology

Research Interests

  • Mechanisms in the initiation of parturition
  • Molecular Mechanisms in the developmental, hormonal and tissue-specific regulation of surfactant protein gene expression in fetal lung tissue
  • Molecular mechanisms in the regulation of aromatase in estrogen-producing cells

Publications

Featured Publications Legend

Featured Publications

Estrogen-related Receptor ? (ERR?) Serves a Role in Blood Pressure Homeostasis during Pregnancy.

Luo Y, Kumar P, Chen CC, Latham J, Wang L, Tudela C, Alexander JM, Shelton JM, McKown L, Mendelson CR Mol. Endocrinol. 2014 Apr me20141003

Estrogen-Related Receptor ? (ERR?) Regulates Oxygen-Dependent Expression of Voltage-gated Potassium (K+) Channels and Tissue Kallikrein during Human Trophoblast Differentiation.

Luo Y, Kumar P, Mendelson CR Mol. Endocrinol. 2013 Apr

The c-Myc Regulated microRNA (miR)-17~92 and miR-106a~363 Clusters Target CYP19A1 and hGCM1 to Inhibit Human Trophoblast Differentiation.

Kumar P, Luo Y, Tudela C, Alexander JM, Mendelson CR Mol. Cell. Biol. 2013 Feb

Results 1-10 of 113

Honors/Awards

  • SGI-Pardi President's Distinguished Scientist Award, Society for Reproductive Investigation
    Award for Scientific Excellence (2014)
  • Mentor Award
    Women in Endocrinology (2010)
  • Vice-President, Basic Science
    The Endocrine Society (2008-2011)
  • Alpha Omega Alpha
    Honor Society (2002)
  • Roy O. Greep Award
    The Endocrine Society (2001)
  • NIH MERIT Award
    Regulation of SP-A Expression in Fetal Lung (1998-2008)